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US 2022/0175689 A1Published application
Novel drug delivery composition and process for blood-brain barrier crossing
AssigneePhosphorex, Inc.
InventorsBin Wu, Nicholas Boylan, Zimeng Wang, Jieni XU
Life of this patent
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Abstract
This invention provides polymeric nanoparticles presenting non-conjugated BBB-crossing ligands on their surfaces, compositions and methods of use thereof, as well as non-conjugation methods to produce nanoparticles having BBB-crossing agents on their surfaces.
Claims26
Particles comprising a biodegradable polymer and a blood brain barrier (BBB)-crossing agent intertwined on the surface thereof, wherein the BBB-crossing agent is a peptide or protein having an affinity for a component of the blood brain barrier.
A method for the preparation of microparticles or nanoparticles comprising:
- (1) dissolving a biodegradable polymer (and optionally an active agent, such as a pharmaceutical ingredient (API), or a poorly water soluble compound) in a first solvent to form a polymer solution;
- (2) emulsifying the polymer solution in a solution of a second solvent to form an emulsion, wherein the first solvent is not miscible or partially miscible with the second solvent, and wherein the solution of the second solvent comprises a BBB-crossing agent and a surfactant;
- and, (3) removing the first solvent to form said microparticles or nanoparticles having the BBB-crossing agent intertwined on the surface thereof.
Dependencies are inferred from the claim text.