Polymeric nanoparticles
AssigneeHillstream BioPharma, Inc.
InventorsSURENDER KHARBANDA, HARPAL SINGH, DIKSHI GUPTA
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Abstract
The present invention relates to polymeric nanoparticles comprising a pharmaceutical combination, pharmaceutical compositions comprising the same, and methods for treating certain diseases comprising administering these polymeric nanoparticles to a subject in need thereof.
Claims12
A method of inhibiting P-glycoprotein expression in a cell with elevated P-glycoprotein expression compared to wild type cells of the same cell type comprising administering to the cell with elevated P-glycoprotein expression an effective amount of polymeric nanoparticles comprising a PLA-PEG-PPG-PEG tetra block copolymer or a PLA-PEG-PPG-PEG-PLA penta block copolymer.
A method for inhibiting proliferation of a cancer cell with elevated P-glycoprotein expression compared to wild type cells of the same cell type in a subject in need thereof comprising administering to the subject a therapeutically effective amount of polymeric nanoparticles comprising a PLA-PEG-PPG-PEG tetra block copolymer or a PLA-PEG-PPG-PEG-PLA penta block copolymer.
Dependencies are inferred from the claim text.