Nanoparticles for drug delivery to brain
AssigneeThe Johns Hopkins University
InventorsJung Soo Suk, Karina Negron, Justin Hanes
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Abstract
Non-adhesive brain-permeable nanoparticles as large as 200 nm can diffuse rapidly in the brain ECS preferably made entirely of generally recognized as safe (GRAS) materials having neutral surface charge are described. Synergistic improvement of therapeutic distribution enabled by these non-adhesive, brain-permeable nanoparticles and osmosis-driven brain extracellular matrix (ECM) modulation will significantly enhance drug and gene delivery within the CNS, offering higher drug payload, improved drug loading efficiency, and significantly longer drug release durations.
Claims20
A dosage formulation for delivery of a therapeutic, prophylactic or diagnostic agent to the brain consisting of
- a. nanoparticles having a diameter between 60 and 230 nm, preferably between 80 and 150 nm or 150-200 nm, densely coated with polyethylene glycol or a block copolymer containing polyethylene glycol blocks and having a near neutral charged surface,
- b. an effective amount of a therapeutic, prophylactic or diagnostic agent encapsulated in or on the nanoparticles,
- c. a cryoprotectant such as a sugar like sucrose, and
- d. a pharmaceutically acceptable excipient for delivery into the brain.
A brain-penetrating nanoparticle comprising
- a. hydrophobic core,
- b. a surface altering agent surrounding the hydrophobic core, and
- c. a therapeutic, prophylactic, or diagnostic agent
- wherein the therapeutic, prophylactic, or diagnostic agent is associated with the hydrophobic core,
- wherein the nanoparticle having a diameter between 150 and 250 nm.
Dependencies are inferred from the claim text.