Nanoparticle, method for producing nanoparticle, and pharmaceutical composition

2:

• The nanoparticle according to claim 1,
• wherein the volume average particle diameter is 5 nm or greater but 150 nm or less.

3:

• The nanoparticle according to claim 1,
• wherein the (R.S.F) satisfies:
• 0<(R.S.F)≤0.6.

4:

• The nanoparticle according to claim 1,
• wherein the poorly-water-soluble physiologically active compound is a kinase inhibitor, or polypeptide, or both.

6:

• The nanoparticle according to claim 1,
• wherein the additive substance is at least one selected from the group consisting of polyoxyl 40 stearate, polysorbate 80, and stearic acid.

7:

• The nanoparticle according to claim 1,
• wherein the poorly-water-soluble physiologically active compound is a pharmaceutical compound.

8:

• A pharmaceutical composition comprising:
• the nanoparticle according to claim 1.

9:

• A method for producing a nanoparticle, the method comprising:
• ejecting a solution including a poorly-water-soluble physiologically active compound from an ejection outlet including one or more pores each having an inner diameter of 1.0 mm or less into a poor solvent including an additive substance to thereby produce the nanoparticle, where the poor solvent is a poor solvent for the poorly-water-soluble physiologically active compound,
• wherein the nanoparticle is the nanoparticle according to claim 1.

10:

• The method according to claim 9,
• wherein the solution is ejected from the ejection outlet by applying vibrations to the solution.

11:

• The method according to claim 9,
• wherein the solution including the poorly-water-soluble physiologically active compound is ejected from the ejection outlet into the poor solvent that flows.

12:

• The method according to claim 11,
• wherein a speed at which the poor solvent flows is 0.3 m/s or faster.