Formulations for encapsulation and bioavailability improvement of bioactive compounds based on natural plant based materials

A particle comprising a plant oil encapsulated in an amphiphilic shell, wherein said amphiphilic shell comprises an amphiphilic plant protein and a hydrophobic compound, wherein the w/w ratio of said hydrophobic compound to said plant protein ranges from 0.01:1 to 1:1, and wherein the w/w ratio of said plant protein to said plant oil ranges from 0.1:1 to 10:1.

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A particle comprising a hydrophobic core and an amphiphilic shell, wherein said hydrophobic core comprises a hydrophobic compound, wherein said amphiphilic shell comprises a first layer and a second layer, wherein said first layer comprises a surfactant and said second layer comprises an amphiphilic plant protein, wherein the w/w ratio of said amphiphilic plant protein to said surfactant ranges from 1:1 to 500:1, and wherein the w/w ratio of said hydrophobic compound to said surfactant ranges from 0.01:1 to 1:10 of said particle.

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A method for solubilizing a hydrophobic compound in an aqueous formulation, comprising:

• (i) mixing said hydrophobic compound and a plant oil at a w/w ratio ranging from 0.01:1 to 1:1 at 30-70° C., to obtain an oil phase, (ii) providing an aqueous solution comprising an aqueous phosphate buffer and an amphiphilic plant protein, (iii) adding said aqueous solution to said oil phase to obtain a final solution, (iv) homogenizing said final solution, thereby solubilizing said hydrophobic compound in said aqueous formulation.

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