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US 2022/0175668 A1Published application
Aqueous ophthalmic solutions of phentolamine and medical uses thereof
AssigneeOcuphire Pharma, Inc.
InventorAlan R. Meyer
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Abstract
The invention provides aqueous ophthalmic solutions of phentolamine or pharmaceutically acceptable salts thereof, medical kits, and methods for using such ophthalmic solutions to improve visual performance in a patient. Exemplary aqueous ophthalmic solutions include those containing phentolamine mesylate, mannitol, sodium acetate, and water.
Claims22
An aqueous ophthalmic solution comprising:
- a. 0.1% (w/v) to 4% (w/v) of phentolamine or a pharmaceutically acceptable salt thereof;
- b. 1% (w/v) to 6% (w/v) of at least one polyol compound having a molecular weight less than 250 g/mol;
- c. 0.1 mM to 10 mM of at least one buffer;
- and
- d. water;
- wherein the solution has a pH in the range of 4.0 to 7.5 and does not contain an additional component that is a chelating agent.
3 more elements
Dependencies are inferred from the claim text.