US 2022/0175667 A1 · Extracellular Matrices, Uses Thereof, and Methods of Making Extracellular Matrices

Abstract

The invention is directed to extracellular matrix replacement (EMR)-drug conjugates, EMR-fluorescent label conjugates, EMR-cell compositions; to methods of making the EMR-drug conjugates, EMR-fluorescent label conjugates, or EMR-cell compositions; to pharmaceutical compositions comprising the EMR-drug conjugates, EMR-fluorescent label conjugates, or EMR-cell combinations; and to methods of treating wounds using the EMR-drug conjugates, EMR-fluorescent label conjugates, or EMR-cell compositions. The invention is also directed to cure-in-place (CIP) EMRs, to methods of making the CIP EMRs, to pharmaceutical compositions comprising the CIP EMRs, and methods of treating wounds using the CIP EMRs.

Claims29

Dependent claims

A cure-in-place extracellular matrix replacement (CIP-EMR) comprising a high-viscosity solution wherein the high viscosity solution comprises:

(a) at least one functionalized dextran, wherein the functionalized dextran is a dextran functionalized with ethylamine, allylcarbamate, or mixtures thereof;
(b) cells that are stem cells;
fibroblasts;
keratinocytes;
endothelial cells;
nerve cells;
adipocytes;
chondrocytes;
osteocytes;
myocytes;
or combinations thereof;
and
(c) optionally comprising an acrylate-comprising compound and/or functionalized acrylate-comprising compound selected from the group consisting of polyethylene(glycol)diacrylate, polyethylene(glycol)acrylate, and acrylate-polyethylene(glycol)-succinimidyl valeric acid, Arg-Gly-Asp-polyethylene(glycol)acrylate (RGD-PEG-acrylate);
Asp-Gly-Arg-polyethylene(glycol)acrylate (DGR-PEG-acrylate);
and mixtures thereof.

12 more elements

Dependencies are inferred from the claim text.

Extracellular Matrices, Uses Thereof, and Methods of Making Extracellular Matrices

Life of this patent

Extracellular Matrices, Uses Thereof, and Methods of Making Extracellular Matrices

Life of this patent

Abstract

Claims29