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US 2022/0175664 A1Published application
Tumescent infiltration drug delivery of high subcutaneous drug concentrations with prolonged local and systemic effects and minimal local or systemic toxicity
AssigneeHK Pharma
InventorsJEFFREY ALAN KLEIN, PAYTRA ALAN KLEIN
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Abstract
A tumescent composition comprising a chemotherapy agent in a tumescent solution, wherein a tumescent concentration of the chemotherapy agent is simultaneously below a threshold for local, subcutaneous tissue toxicity, above a threshold for positive local therapeutic effect, and above a concentration safely achievable by intravenous (IV), intramuscular (IM) or oral (PO) delivery; and the tumescent solution comprises a vasoconstrictor; a pharmaceutically acceptable carrier; and optionally a local anesthetic.
Claims18
A tumescent composition comprising a chemotherapy agent in a tumescent solution, wherein:
- (a) a tumescent concentration of the chemotherapy agent is simultaneously:
- 1) below a threshold for local, subcutaneous tissue toxicity,
- 2) above a threshold for positive local therapeutic effect, and
- 3) above a concentration safely achievable by intravenous (IV), intramuscular (IM) or oral (PO) delivery;
- and
- (b) the tumescent solution comprises:
- (i) a vasoconstrictor;
- (ii) a pharmaceutically acceptable carrier;
- and
- (iii) optionally a local anesthetic.
7 more elements
Dependencies are inferred from the claim text.