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US 2022/0175622 A1Published application
Double-layered denture comprising nanoparticles
AssigneeImam Abdulrahman Bin Faisal University
InventorsMohammed Moustafa Ahmed GAD, Reem ABUALSAUD, Ahmed Mohamed RAHOMA, Shaimaa Mohamed Said FOUDA, Ahmad M. AL-THOBITY
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Abstract
Base material arrangements having at least two layers can accommodate the addition of antifungal material (nanofiller), such as in denture base resin without significantly compromising the mechanical properties and/or translucency of the base material arrangements. Antifungal agents such as nanosilver and nanozirconia can be used to modify a surface layer of the material arrangements, such as the denture base, to overcome certain known shortcomings of the modified materials, e.g., typical acrylic resins containing nanosilver and nanozirconia.
Claims20
1:
- A dental restoration base material, comprising:
- a first layer comprising at least 90 wt. %, relative to total first layer weight, of a cured first composition comprising, prior to curing, a first (meth)acrylic polymer and a first (meth)acrylic monomer;
- and
- a surface layer comprising at least 90 wt. %, relative to total surface layer weight, of a cured second composition comprising, prior to curing, a second (meth)acrylic polymer, a second (meth)acrylic monomer, and
- 0.1 to 5 wt. % of antimicrobial nanoparticles, relative to a total surface layer weight, wherein no gradient in antimicrobial nanoparticle content and no continuous bulk containing the antimicrobial nanoparticles is present between the first and surface layers, and
- wherein the first layer comprises no more than 10% as much of the antimicrobial particles as the surface layer.
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2:
- The material of claim 1, comprising 0.25 to 2 wt. % of the antimicrobial nanoparticles, wherein the antimicrobial nanoparticles comprise silver nanoparticles.
3:
- The material of claim 2, wherein the silver nanoparticles have an average particle size of 5 to 40 nm.
4:
- The material of claim 1, comprising 0.25 to 2 wt. % of the antimicrobial nanoparticles, wherein the antimicrobial nanoparticles comprise zirconium dioxide nanoparticles.
5:
- The material of claim 4, wherein the zirconium dioxide nanoparticles have an average particle size of 20 to 60 nm.
6:
- The material of claim 2, wherein the antimicrobial nanoparticles further comprise zirconium dioxide nanoparticles.
7:
- The material of claim 1, wherein the antimicrobial nanoparticles comprise no more than 0.1 wt. % organic compounds, relative to the total material weight.
8:
- The material of claim 1, wherein the surface layer directly contacts the first layer on at least portions of the first layer.
9:
- The material of claim 1, arranged such that, in operation, the surface layer is configured to contact oral fluids and to shield any layers below the surface layer, including the first layer, from the oral fluids.
10:
- The material of claim 1, wherein the surface layer has a thickness no more than 20% that of a total material thickness.
11:
- The material of claim 1, wherein the surface layer has a thickness of 100 to 3,000 μm.
12:
- The material of claim 1, wherein the first (meth)acrylic polymer and the second (meth)acrylic polymer each comprise at least 90 wt. % poly(methyl methacrylate).
13:
- The material of claim 1, wherein the first (meth)acrylic monomer and the second (meth)acrylic monomer each comprise at least 90 wt. % methyl methacrylate.
14:
- The material of claim 1, wherein the first (meth)acrylic polymer and the second (meth)acrylic polymer are the same,
- wherein the first (meth)acrylic monomer and the second (meth)acrylic monomer are the same, and
- wherein the first and the second (meth)acrylic monomer are suitable to form the same polymer as the first and the second (meth)acrylic polymer.
15:
- The material of claim 1, which is suitable to reduce Candida adhesion to a dental prosthesis by at least 10%, relative to materials comprising the first layer alone.
16:
- The material of claim 1, which has a flexural strength in a range of from 60 to 100 MPa,
- which has a translucency parameter in a range of from 2 to 15, and/or
- wherein the surface layer has a surface roughness in a range of from 0.1 to 0.4 μm.
17:
- A denture, comprising the material of claim 1.
18:
- A method of preventing or reducing adhesion of a microorganism to a dental restoration, the method comprising inserting into an oral cavity of a subject in need thereof the dental restoration comprising the material of claim 1;
- and maintaining the dental restoration in the oral cavity for at least 3 hours.
19:
- The method of claim 18, wherein the microorganism is a Candida species of fungus.
20:
- A method of making a dental restoration base material, the method comprising:
- prepolymerizing a first composition comprising a first (meth)acrylic monomer and a first (meth)acrylic polymer, to obtain a first viscous composition;
- conforming the first viscous composition into a dental mold;
- prepolymerizing a second composition comprising a second (meth)acrylic monomer, 0.1 to 5 wt. %, relative to a total second composition weight, of antimicrobial nanoparticles, and a second (meth)acrylic polymer, to obtain a second viscous composition;
- conforming the second viscous composition into the dental mold over the first viscous composition;
- polymerizing the first and second viscous compositions in the dental mold, thereby forming a restoration base material.
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