Adhesive ostomy wafer including a stomareceiving hole and a neutralizer contained in an envelope, with the envelope extending to an edge of the stoma-receiving hole

An adhesive ostomy wafer attachable around a stoma of a user, where the adhesive ostomy wafer is adapted to secure a waste collecting device to the user to collect waste from the stoma, the adhesive ostomy wafer comprising:

• a backing layer that is gas and water impermeable;
• a first adhesive deposited onto a proximal side of the backing layer;
• a skin-facing adhesive located proximal of the first adhesive and adapted to adhere the adhesive ostomy wafer to skin around the stoma of the user;
• and
• a neutralizer located in an envelope that is contained by the adhesive ostomy wafer between the first adhesive and the skin-facing adhesive, where the neutralizer is a potato-derived inhibitor or a protease inhibitor;
• wherein the envelope comprises a distal layer separating the neutralizer from the first adhesive, a proximal layer separating the neutralizer from the skin-facing adhesive, with the distal layer sealed to the proximal layer at a location where the envelope is closest to an outer perimeter of the adhesive ostomy wafer;
• wherein the adhesive ostomy wafer includes a stoma-receiving hole formed through the backing layer, the first adhesive, the neutralizer and the envelope, and the skin-facing adhesive, with the first adhesive, the neutralizer, and the skin-facing adhesive exposed within the stoma-receiving hole.