Liquid collagen bioinks and methods to make and use collagen structures
AssigneeThe Curators of the University of Missouri
InventorsSheila Grant, Colten Snider, David Grant
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Abstract
The present disclosure provides collagen bioink compositions and chemically uncrosslinked and crosslinked collagen structures including collagen microparticles and scaffolds. Also provided are methods of their fabrication and use. Applications for using these collagen structures include treatments of damaged tissue, particularly those caused by osteoarthritis.
Claims34
A collagen bioink composition comprising collagen, a polar solvent, and a stabilizing divalent ion chelating agent, wherein the collagen bioink fibrilizes when introduced into a printing solution substantially free of a crosslinker.
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The chemically uncrosslinked collagen structure of claim 23, wherein the structure comprises a plurality of collagen microparticles.
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Dependencies are inferred from the claim text.