Transcatheter heart valve prostheses

A transcatheter aortic valve prosthesis for replacement of a native heart valve, the transcatheter aortic valve prosthesis comprising:

• a frame having a plurality of struts, a plurality of crowns at an inflow end, a plurality of crowns at an outflow end, a plurality of commissure posts or commissure cells, a plurality of first cells, and at least one access cell, wherein the frame includes a row of the plurality of struts which includes a plurality of standard struts and a plurality of optimized struts, each standard strut of the plurality of standard struts having a first width profile and a first length, and each optimized strut of the plurality of optimized struts having a width profile that is different from the first width profile and a length that is different from the first length;
• and
• a valve component including two or more valve leaflets disposed within the frame, wherein a commissure is formed where two valve leaflets of the two or more valve leaflets are attached to each other and each commissure is secured to a commissure post or commissure cell of the plurality of commissure posts or commissure cells of the frame, and
• wherein an area of a first cell directly adjacent to the at least one access cell has a first area and the at least one access cell has a second area, the second area being at least twice as large as the first area, and
• wherein the at least one access cell is centered in a circumferential direction between two commissure posts or commissure cells of the plurality of commissure posts or commissure cells of the frame, and
• wherein the row of the plurality of struts which includes the plurality of standard struts and the plurality of optimized struts is disposed at an inflow end or an outflow end of the at least one access cell.