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US 2022/0175511 A1Published application
Macroencapsulation devices
AssigneeVertex Pharmaceuticals Incorporated
InventorsChristopher Thanos, Danya M. Lavin, John Mills, Megan Billings
Life of this patent
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Abstract
The present disclosure relates to macroencapsulation devices and related methods of manufacture where the membranes of a device may be mounted to an associated frame in a relaxed, or slack, configuration prior to filling with a desired material.
Claims42
A macroencapsulation device for housing a population of cells comprising:
- a first membrane;
- a second membrane disposed on the first membrane, wherein the first membrane and the second membrane are bonded along a perimeter of the first and second membranes to form an internal volume there between, wherein the first membrane and/or the second membrane is semipermeable;
- and
- a frame that extends along at least a portion of the perimeter of the first and second membranes, and wherein a surface area of the first and/or second membrane is greater than a transverse cross sectional area of the frame the first and second membranes are mounted within.
1 more element
A macroencapsulation device for housing a population of cells comprising:
- a first membrane;
- a second membrane disposed on the first membrane, wherein the first membrane and the second membrane are bonded along a perimeter of the first and second membranes to form an internal volume there between, wherein the first membrane and/or the second membrane is semipermeable;
- and
- a frame that extends along at least a portion of the perimeter of the first and second membranes, and wherein a portion of the first and second membranes connected to the frame is deformed to fit within an area of the frame that is smaller than an area of the portion of the first and second membranes in an undeformed configuration.
1 more element
A method of forming a macroencapsulation device, the method comprising:
- deforming a portion of a first membrane and a second membrane disposed on the first membrane in a direction out of a plane of the first and second membranes;
- and
- connecting a frame to the second membrane and/or the first membrane while the portion of the first and second membranes is deformed out of plane, wherein the frame limits a maximum transverse dimension of the macroencapsulation device, wherein the first membrane and/or the second membrane is semipermeable.
A method of forming a macroencapsulation device, the method comprising:
- deforming an outer perimeter of a first membrane and a second membrane disposed on the first membrane from a first maximum transverse dimension to a second maximum transverse dimension smaller than the first maximum transverse dimension;
- and
- connecting a frame to the second membrane and/or the first membrane to limit the maximum transverse dimension of the first and second membranes to the second maximum transverse dimension, wherein the first membrane and/or the second membrane is semipermeable.
Dependencies are inferred from the claim text.