Brain-based system and methods for evaluating treatment efficacy testing with objective signal detection and evaluation for individual, group or normative analysis

A method of implementing a substitution analysis comprising:

• providing a set of patient electrodes;
• providing an EEG device, including a first memory, operatively connected to the set of patient electrodes;
• providing a signal processing computer, including a second memory, operatively connected to the EEG device;
• providing a set of instructions, resident in the first memory and the second memory, that execute the steps of:
• identifying a set of signal test samples;
• dividing the set of signal test samples into a pre-treatment group and a post-treatment group;
• point-for-point averaging the pre-treatment group to derive a pre-treatment average;
• point-for-point averaging the post-treatment group to derive a post-treatment average;
• subtracting the pre-treatment average from the post-treatment average to derive an obtained difference;
• implementing a substitution analysis on the pre-treatment group and the post-treatment group to derive an average substituted obtained difference;
• determining a percent change between the average substituted obtained difference and the obtained difference;
• and,
• reporting the percent change.