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AssigneesAlbert Einstein College of Medicine, Washington University
InventorsVladislav V. Verkhusha, Andrii A. Kaberniuk, Lihong Wang, Junjie Yao, Lei Li
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Reversibly switchable photoacoustic tomography (RS-PAT), a photoacoustic technique with enhanced sensitivity and resolution, is disclosed. RS-PAT utilizes a subtractive process for the formation of a photoacoustic image of a region containing a plurality of switchable photoacoustic probes. In various aspects, the photoacoustic detection in RS-PAT imaging occurs minimally twice: a first image obtained when the photoacoustic probe is in active (absorbing or ON) state and a second image obtained when the photoacoustic probe is in an inactive (less-absorbing or OFF) state. Subtraction of the second image from the first image is used to obtain the RS-PAT image.
A method of obtaining a differential PA image of a region of interest, the method comprising:
A reversibly-switchable probe for use in differential PA imaging, the reversibly-switchable probe comprising a protein with photoswitchable absorption, wherein the reversibly-switchable probe is either endogenously produced by at least one cell to be imaged or is exogenously introduced into at least a portion of a field of view to be imaged using the differential PA imaging.
10-20. (canceled)
Dependencies are inferred from the claim text.