Aminoacyl-trna synthetase for efficiently introducing lysine derivative in protein
AssigneeNingbo Kunpeng Biotech Co., Ltd.
InventorsSong WU, Zhenshan ZHANG, Huiling LIU, Wei CHEN
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Abstract
Provided is a mutant lysyl-tRNA synthetase. Compared with a wild-type lysyl-tRNA synthetase, the mutant lysyl-tRNA synthetase of the present invention can increase the amount of non-natural amino acids inserted and the amount of a protein of interest containing non-natural amino acids, and can also improve the stability of the protein of interest, thereby making same less prone to fragmentation.
Claims11
A mutant lysyl-tRNA synthetase, wherein the mutant lysyl-tRNA synthetase has a mutation at the position 19 arginine (R) and/or the position 29 histidine (H) in the amino acid sequence corresponding to the wild-type lysyl-tRNA synthetase.
Dependencies are inferred from the claim text.