Methods for modulating inflammasome activity and inflammation in the lung
AssigneeUniversity of Miami
InventorsRobert W. KEANE, W. Dalton DIETRICH, Nadine KERR, Shu WU, Juan Pablo DE RIVERO VACCARI
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Abstract
The present invention provides compositions and methods for reducing inflammation in the lungs of a mammal that is afflicted by a condition that leads to inflammation in the lungs. The compositions and methods described herein include agents that inhibit inflammasome signaling in the mammal such as antibodies directed against inflammasome components used alone or in combination with extracellular vesicle uptake inhibitor(s).
Claims42
A method of treating inflammation in lungs of a patient in need thereof, the method comprising:
- administering to the patient a composition comprising an agent that inhibits inflammasome signaling, whereby the inflammation in the lungs of the patient is treated.
The method of any one of the above claims, wherein the administration of the composition results in inhibition of inflammasome activation in lung cells of the patient.
The method of any one of the above claims, wherein the agent is an extracellular vesicle (EV) uptake inhibitor, an antibody that binds to an inflammasome component or a combination thereof.
The method of any one of the above claims, wherein the composition is formulated with a pharmaceutically acceptable carrier or diluent.
The method of any one of the above claims, wherein the composition is administered intracerebroventricularly, intraperitoneally, intravenously or by inhalation.
A method of treating inflammation in lungs of a patient that has been subjected to a central nervous system (CNS) injury, the method comprising:
- administering to the patient a composition comprising an agent that inhibits inflammasome signaling, whereby the inflammation in the lungs of the patient is treated.
Dependencies are inferred from the claim text.