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US 2022/0169686 A1Published application
Variant of a bpifb4 protein
AssigneeRoxiant Aps
InventorsAnnibale Alessandro PUCA, Carmine Vecchione
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Abstract
The present invention relates to a variant of BPIFB4 protein (Bactericidal/Permeability Increasing protein family B, member 4) and to a polynucleotide or a vector encoding said variant of BPIFB4 protein and to their use for the treatment of pathologies involving impairment of nitric oxide signalling.
Claims14
-17. (canceled)
An isolated polynucleotide encoding a BPIFB4 protein variant consisting of the aminoacid sequence of SEQ ID NO:
- 1, said protein variant having activity in increasing the activity of eNOS and/or the production of NO.
Dependencies are inferred from the claim text.