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US 2022/0169599 A1Published application
Arylsulfonamide derivatives
AssigneeHoffmann-La Roche Inc.
InventorsBarbara BIEMANS, Luca GOBBI, Georg JAESCHKE, Henner KNUST, Lothar LINDEMANN, Fionn O'HARA, Jean-Marc PLANCHER
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Abstract
The present invention provides new arylsulfonamide compounds having the general formula (I) wherein L, R1, R2, R3 and R4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
Claims24
A compound of formula (I)
- wherein
- L is a bond or —C≡C—;
- R1 is phenyl optionally substituted with 1 or 2 substituents independently selected from halogen, hydroxy, lower alkyl, lower alkoxy or haloalkyl;
- or
- pyridyl optionally substituted with halogen, lower alkyl, lower alkoxy or haloalkyl;
- or
- pyrazolyl optionally substituted with halogen, hydroxy, lower alkyl, lower alkoxy or haloalkyl;
- R2 is phenyl optionally substituted with 1 to 3 substituents selected from halogen, hydroxy, lower alkyl, lower alkoxy, haloalkyl or alkoxyalkyl;
- or
- a heteroaryl group optionally substituted with halogen, hydroxy, lower alkyl, lower alkoxy, haloalkyl or alkoxyalkyl, selected from
- R3 and R4 are halogen, haloalkyl, lower alkyl or lower alkoxy;
- or a pharmaceutically acceptable salt thereof.
9 more elements
The invention as hereinbefore described.
Dependencies are inferred from the claim text.