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US 2022/0167600 A1Published application
Methods for producing antigen-binding proteins against foreign antigens
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsVera Voronina, Lynn Macdonald, Marine Prissette, Ka-Man Venus Lai, Ashok Badithe, Andrew J. Murphy, Gustavo Droguett, David Frendewey, Brian Zambrowicz
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Abstract
Methods and compositions are provided for generating antigen-binding proteins against a foreign antigen of interest.
Claims1
A method of generating antigen-binding proteins against a foreign antigen of interest, comprising:
- (a) making a non-human animal with reduced tolerance of a foreign antigen of interest;
- (b) immunizing the non-human animal produced in step (a) with the foreign antigen of interest;
- and
- (c) maintaining the non-human animal under conditions sufficient to initiate an immune response to the foreign antigen of interest, wherein the non-human animal produces antigen-binding proteins against the foreign antigen of interest.
1 more element
Dependencies are inferred from the claim text.