Methods of diagnosing and treating multiple sclerosis with vascular endothelial biomarkers

A method of diagnosing and treating Multiple Sclerosis (MS) in a patient comprising:

• obtaining a sample from the patient;
• determining a level of one or more H2S generating enzymes in the sample from the patient;
• diagnosing the patient with MS when the level of the one or more H2S generating enzymes in the sample is one of
• at least 15% higher or lower than a control level for the one or more H2S generating enzymes, and
• at least 10% higher or lower than a control level for the one or more H2S generating enzymes, and
• administering an effective amount of one of
• an H2S generating enzyme inhibitor to the diagnosed patient if the one or more H2S generating enzymes level in the sample is elevated, and
• additional H2S generating enzyme substrate and or H2S generating enzyme genetic augmentation to the diagnosed patient if the one or more H2S generating enzymes level in the sample is decreased.