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US 2022/0162655 A1Published application
Engineered biosynthetic pathways for production of l-homocysteine by fermentation
AssigneeZymergen Inc.
InventorsMichael Shareef Siddiqui, Alexander Glennon Shearer, Franklin Lu, Stefan de Kok, Cara Ann Tracewell, Steven M. Edgar, Jennifer Yip
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Abstract
The present disclosure describes the engineering of microbial cells for fermentative production of L-homocysteine and provides novel engineered microbial cells and cultures, as well as related L-homocysteine production methods.
Claims28
An engineered microbial cell that comprises increased activity of at least one upstream pathway enzyme leading to L-homocysteine, wherein the at least one upstream pathway enzyme is selected from the group consisting of:
- (a) 3-phosphoadenosine-5-phosphosulfate sulfotransferase (PAPS reductase),
- (b) sulfite reductase, and
- (c) sulfate adenylyltransferase (ATP sulfurase),
- said increased activity being increased relative to a control cell, wherein the engineered microbial cell produces L-homocysteine.
1 more element
Dependencies are inferred from the claim text.