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AssigneesTurnstone Biologics Corp., Children's Hospital of Eastern Ontario Research Institute Inc.
InventorsDavid Stojdl, Justyna KMIECIK, Michael F. BURGESS
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In one aspect, provided herein is a heterologous boost method for inducing an immune response to at least one neoantigen, the method comprising administering to a subject a first boost and subsequently administering to the subject a second boost, wherein the first boost comprises a first oncolytic virus comprising a genome that expresses, in the subject, a first peptide, or the first boost comprises a first oncolytic virus and a second peptide, wherein the second boost comprises a second oncolytic virus comprising a genome that expresses, in the subject, a third peptide, or the second boost comprises a second oncolytic virus and a fourth peptide, wherein the first peptide, the second peptide, the third peptide, and the fourth peptide are each capable of inducing an immune response to at least one neoantigen, and wherein the second oncolytic virus is immunologically distinct from the first oncolytic virus. The subject may have pre-existing immunity to the at least one neoantigen. The subject may have been administered a priming composition before receiving the first boost, wherein the priming composition is capable of inducing an immune response to the at least one neoantigen.
A method of inducing an immune response to at least one neoantigen in a subject with pre-existing immunity to the at least one neoantigen, or a subject who has previously been administered a dose of a priming composition that is capable of inducing an immune response to the at least one neoantigen, the method comprising:
A method of inducing an immune response to at least one neoantigen in a subject with pre-existing immunity to the at least one neoantigen, or a subject who has previously been administered a dose of a priming composition that is capable of inducing an immune response to the at least one neoantigen, the method comprising:
A method of inducing an immune response to at least one neoantigen in a subject, comprising administering to the subject a second boost comprising (i) a dose of a second composition, wherein the second composition comprises a second oncolytic virus and a first peptide composition, or (ii) a dose of a third composition and a dose of a fourth composition, wherein the third composition comprises the second oncolytic virus, and the fourth composition comprises the first peptide composition, wherein the first peptide composition is capable of inducing an immune response to the at least one neoantigen, wherein the third and fourth compositions are administered concurrently or sequentially to the subject,
A method of inducing an immune response to at least one neoantigen in a subject, comprising administering to the subject a second boost comprising a dose of a fourth composition, wherein the fourth composition comprises a second oncolytic virus that comprises a genome comprising a first transgene, wherein the first transgene encodes and expresses a first protein that is expressed in the subject, wherein the first protein or a fragment thereof is capable of inducing an immune response to the at least one neoantigen,
A method of inducing an immune response to at least one neoantigen in a subject with pre-existing immunity to the neoantigen, or a subject who has previously been administered a dose of a priming composition that is capable of inducing an immune response to the at least one neoantigen, the method comprising:
A method of inducing an immune response to at least one neoantigen in a subject, comprising administering the subject a second boost comprising (i) a dose of a fourth composition, wherein the fourth composition comprises a second oncolytic virus and a second peptide composition, or (ii) a dose of a fifth composition and a dose of a sixth composition, wherein the fifth composition comprises the second oncolytic virus, and the sixth composition comprises the second peptide composition, wherein the fifth and sixth compositions are administered concurrently or sequentially to the subject,
A method of inducing an immune response to at least one neoantigen in a subject, comprising:
A method of inducing an immune response to at least one neoantigen in a subject with pre-existing immunity to the at least one neoantigen, or a subject who has previously been administered a dose of a priming composition that is capable of inducing an immune response to the at least one neoantigen, the method comprising:
A method of inducing an immune response to at least one neoantigen in a subject, the method comprising to the subject a second boost comprising a dose of a second composition, wherein the second composition comprises a second oncolytic virus that comprises a genome comprising a second transgene, wherein the second transgene encodes and expresses a second protein in the subject, wherein the second peptide or a fragment thereof is capable of inducing an immune response to the at least one neoantigen,
A method of inducing an immune response to at least one neoantigen in a subject, comprising:
A method of inducing an immune response to at least one neoantigen in a subject, comprising:
A method of inducing an immune response to at least one neoantigen in a subject, comprising:
Dependencies are inferred from the claim text.