System for restoring patency across an obstruction

A system for crossing a vascular occlusion and restoring blood flow within a vessel, the system comprising:

• a retrograde catheter being configured to be inserted into the vessel and comprising:
• a first proximal end,
• a first distal end,
• a first side port being spaced proximally apart from the first distal end,
• a first central lumen extending proximally from the first side port and towards the first proximal end and being in fluid communication the first side port, and
• a guidewire lumen being in a distal region of the retrograde catheter, the guidewire lumen being offset from a longitudinal axis of the retrograde catheter;
• and
• an antegrade catheter being configured to be inserted into the vessel and comprising:
• a second proximal end,
• a hub on the second proximal end,
• a second distal end,
• a second side port on a window region spaced proximally apart from the second distal end, and
• a second central lumen extending between the hub and the second side port and being in fluid communication with the second side port.