Non-canonical lipoproteins with programmable assembly and architecture
AssigneeSyracuse University
InventorDavoud Mozhdehi
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Abstract
Artificial lipoproteins bearing non-canonical post-translational modifications that are synthesized by leveraging substrate promiscuity of an acyltransferase. The non-canonical functionality of these lipoprotein results in a distinctive hysteretic assembly that is absent from the canonical lipoproteins and is used to prepare hybrid multiblock materials with precise and programmable patterns of amphiphilicity due to the unique assembly and function of the non-canonical post-translational modifications.
Claims18
A method of synthesizing a non-naturally occurring lipoprotein, comprising the steps of:
- coexpressing a lipid modification enzyme with an intrinsically disordered peptide-polymer fused to a peptide substrate of the lipid modification enzyme;
- and
- supplementing the expression media with a non-natural fatty acid to form a non-naturally occurring lipoprotein.
A non-naturally occurring lipoprotein, comprising an intrinsically disordered peptide-polymer fused to a fatty acid.
Dependencies are inferred from the claim text.