Antibody molecules and uses thereof
AssigneeThe University Court of the University of Aberdeen
InventorsFiona Marion RUDKIN, Neil Andrew Robert GOW, Louise Ann WALKER
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Abstract
This invention relates to recombinant human antibody molecules for use in a method of treatment of Acinetobacter infection. The antibodies bind Acinetobacter antigens, for example from Acinetobacter spp. Human antibody encoding genes targeting clinically relevant Candida epitopes have been isolated from single B cells from carefully selected donors and screened with specified types of protein or cell wall extract. The panel of purified, fully human recombinant IgG1 mAbs generated displayed a diverse range of specific binding profiles and demonstrated efficacy in a disease model. The fully human mAbs and derivatives thereof have utility in the generation of diagnostics, therapeutics and vaccines.
Claims37
An isolated recombinant human anti-Candida antibody molecule derived from single B cells for use in a method of treatment of an Acinetobacter bacterial infection, wherein the antibody molecule comprises a VH domain comprising a HCDR3 having the amino acid sequence of SEQ ID NO:
- 6x or the sequence of SEQ ID NO:
- 6x with 1, 2, or 3 amino acid substitutions, deletions or insertions, wherein ‘x’ is one letter from F, E, D and C, and said sequence is as shown in Table ‘x’ herein.
Dependencies are inferred from the claim text.