Antagonists of cb1 receptor

A method for the treatment of a pathologic condition or disorder comprising administering to a subject in need thereof a compound of formula (A), or a pharmaceutically acceptable salt thereof:

• wherein:
• denotes that the bond is a single or a double bond,
• R1 denotes that C3 is substituted with
• —H,
• halogen,
• —OH,
• C1-8 alkoxy,
• Bn-O—
• Bn- optionally substituted with C1-8 alkyl, C1-8 alkoxy, cyano, nitro, amino, carboxyl or halogen,
• Ph- optionally substituted with C1-8 alkyl, C1-8 alkoxy, cyano, nitro, amino, carboxyl or halogen,
• ═O,
• —NR5R6 wherein R5 and R6 each independently is H, C1-8 alkyl, Bn or Ph,
• —O—CO—R7 wherein R7 is alkyl,
• —O—CO—C2H4—COOH, or
• —N3,
• —R2 denotes that C17 is substituted with
• —H,
• —OH,
• halogen,
• C1-8 alkyl,
• C1-8 alkoxy,
• C2-6 alkenyl,
• Bn optionally substituted with C1-8 alkyl, C1-8 alkoxy, cyano, nitro, amino, carboxyl or halogen,
• Ph- optionally substituted with C1-8 alkyl, C1-8 alkoxy, cyano, nitro, carboxyl or halogen, or
• Bn-O—,
• R3 denotes that C20 is substituted with
• —H,
• —OH,
• C1-8 alkyl,
• Bn,
• —NR8R9 wherein R8 and R9 each independently is H, C1-8 alkyl or Bn,
• ═CR10R11 wherein R10 and R11 each independently is H or C1-7 alkyl, or
• ═O
• R4 denotes that C16 is substituted with
• —H,
• —OH, or
• ═O,
• with the proviso that
• when the bond between C16 and C17 is double, R2 is absent and the bond between C17 and C20 is single, and
• when the bond between C17 and C20 is double, C20 is substituted with —H or —OH and R2 is absent,
• when the bond between C4 and C5 is double, the bond between C5 and C6 is single and inversely,
• wherein the pathologic condition or disorder is selected from the group consisting of bladder and gastrointestinal disorders;
• inflammatory diseases;
• cardiovascular diseases;
• nephropathies glaucoma;
• spasticity;
• cancer;
• osteoporosis;
• metabolic disorders;
• obesity;
• addiction, dependence, abuse and relapse related disorders;
• psychiatric and neurological disorders;
• neurodegenerative disorders;
• autoimmune hepatitis and encephalitis;
• pain;
• reproductive disorders;
• and skin inflammatory and fibrotic diseases.