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US 2022/0153685 A1Published application
Small molecule ampk activators
AssigneesUniversity of Pittsburg-Of the Commonealth System of Higher Education, The United States AS Represented By the Department of Veterans Affairs
InventorsBeibei Chen, Rama K. Mallampalli, Yuan Liu
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Abstract
Described herein are compounds that disrupt the interaction between Fbxo48 and phosphorylated-AMPK.
Claims20
(canceled)
A compound of Formula II:
- wherein:
- X is —O—CH2—;
- Z is CH2;
- at least one of R1 and R2 is —(CHRA)b—Y, wherein each RA is independently H;
- and b is 1;
- the remaining one of R1 and R2 is (CH2)—Y;
- and
- each Y is independently phenyl or substituted phenyl;
- R3 is phenyl substituted by one
- wherein
- A is —(C(RB)2)d—, wherein each RB is independently selected from H, D, halogen, OH, substituted or unsubstituted alkyl, and substituted or unsubstituted alkoxy;
- d is 0;
- and
- B is selected from the group consisting of C2-6 alkyl, haloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, and unsubstituted heteroaryl;
- or a stereoisomer thereof, or a pharmaceutically acceptable salt or ester thereof.
12 more elements
A compound selected from the group consisting of
- or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.