Sticky particles for efficient imaging
AssigneeThe Johns Hopkins University
InventorsGuanshu Liu, Zheng Han
Life of this patent
Estimating the term…
Abstract
Described are compositions and methods of manufacturing extracellular vesicles comprising sticky imaging particles. In one aspect, methods include associating a sticky element to imaging particles forming sticky imaging particles. The sticky imaging particles are associated with extracellular vesicles (EV) to form a mixture comprising extracellular vesicles (EV) that comprise sticky imaging particles. The method also include separating the sticky imaging particles associated with EVs from sticky imaging particle that are not associated with EVs.
Claims28
A method for manufacturing extracellular vesicles comprising sticky imaging particles comprising:
- associating one or more sticky elements to one or more imaging particles to form one or more sticky imaging particles;
- forming extracellular vesicles (EV) comprising one or more of the sticky imaging particles.
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8-9. (canceled)
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16-19. (canceled)
A sticky imaging particle comprising:
- an imaging particle;
- and
- one or more sticky elements.
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An imaging composition comprising extracellular vesicles and one or more sticky imaging particles,
- wherein the sticky imaging particles comprise an imaging particle and one or more sticky elements, and the composition has less than 40 weight % of sticky imaging particles that are not associated with extracellular vesicles, where weight % is based on total composition weight.
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Dependencies are inferred from the claim text.