Targeted combination therapy
AssigneesAura Biosciences, Inc., The USA, as represented by the Secretary, Department of Health and Human Service
InventorsElisabet de los Pinos, John Todd Schiller, Rhonda C. Kines
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Abstract
Some embodiments of the present disclosure are directed to methods and compositions for the treatment of tumors, using a combination of immunotherapeutic agents and tumor-targeting viral capsid protein assemblages comprising anti-cancer molecules conjugated to viral capsid proteins.
Claims44
A method comprising
- (a) administering, to a subject having a tumor, a composition comprising tumor-targeting viral capsid protein assemblage that comprises photosensitive molecules conjugated to viral capsid proteins of the assemblage;
- and
- (b) administering to the subject having a tumor, a composition comprising an immune checkpoint inhibitor.
The method of claim 23, wherein the tumor is metastatic.
A method comprising administering an immune checkpoint inhibitor to a subject having a tumor who is undergoing treatment with a tumor-targeting viral capsid protein assemblage that comprises photosensitive molecules conjugated to viral capsid proteins of the assemblage.
A composition comprising an immune checkpoint inhibitor and a tumor-targeting viral capsid protein assemblage that comprises photosensitive molecules conjugated to viral capsid proteins of the assemblage.
Dependencies are inferred from the claim text.