Bacteriophage treatment and reduction in inflammatory response
AssigneeWestern Sydney Local Health District
InventorsChing Yu Lin, Jonathan Ripley Iredell
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Abstract
The present invention relates to the treatment of bacterial infections and the reduction of inflammatory response using bacteriophage compositions. In an aspect, provided herein are methods of treating a bacterial infection characterized by inflammation in a subject, the method comprising administering to the subject a bacteriophage composition that is essentially free of impurities, wherein the composition reduces inflammation.
Claims30
A method of treating a bacterial infection characterized by inflammation in a subject, the method comprising administering to the subject a bacteriophage composition, wherein the bacteriophage composition reduces inflammation.
6-9. (canceled)
The method of claim 9, wherein the antibiotic is a fluoroquinolone, carbapenem, aminoglycoside, cephalosporin, penicillin, beta lactam, or beta lactamase inhibitor.
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A method for determining efficacy of a bacteriophage formulation in a subject receiving bacteriophage therapy to treat an inflammatory bacterial infection, the method comprising:
- a) obtaining a first gene expression profile for two or more informative genes in a first biological sample, wherein the first biological sample is obtained from the subject prior to administration of the bacteriophage therapy;
- b) obtaining a subsequent gene expression profile for the two or more informative genes in a subsequent biological sample, wherein the subsequent biological sample is obtained from the subject after administration of the bacteriophage therapy;
- c) correlating the first gene expression profile and the subsequent gene expression profile, wherein said correlating step comprises assigning the difference in the first and subsequent gene expression profiles a positive, intermediate, or negative assay score;
- and
- d) treating the patient based on the positive, intermediate, or negative assay score wherein comprises therapeutic intervention.
Dependencies are inferred from the claim text.