Methods of promoting cellular maturation with ampk activators
AssigneeUniversity of Washington
InventorsCharles E. MURRY, Xiulan YANG
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Abstract
Described herein are methods and compositions related to promoting maturation of in vitro-differentiated cardiomyocytes and in vitro-differentiated neurons, and methods and compositions using the resulting cardiomyocytes and neurons.
Claims24
A method of promoting maturation of in vitro-differentiated cardiomyocytes, the method comprising treating in vitro-differentiated cardiomyocytes with an activator of adenosine monophosphate-activated protein kinase (AMPK).
(canceled)
A method of transplanting in vitro-differentiated cardiomyocytes in a subject, the method comprising:
- (a) contacting in vitro-differentiated cardiomyocytes with an activator of AMPK;
- and
- (b) transplanting said in vitro-differentiated cardiomyocytes into the subject.
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A composition comprising in vitro-differentiated cardiomyocytes made by contacting in vitro-differentiated cardiomyocytes with an activator of adenosine monophosphate-activated protein kinase (AMPK), wherein the cardiomyocytes have a more mature phenotype as compared with in vitro-differentiated cardiomyocytes that were not contacted with an activator of adenosine monophosphate-activated protein kinase (AMPK).
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Dependencies are inferred from the claim text.