Choline Esters
AssigneeNovartis AG
InventorsWilliam GARNER, Margaret GARNER, George MINNO, David GOODEN
Life of this patent
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Abstract
Compounds, formulations, and methods are provided containing the choline ester of a reducing agent, especially lipoic acid or derivatives thereof. The compounds may be administered via a topical ocular route to treat or prevent oxidative damage.
Claims31
A compound comprising the choline ester of lipoic acid or a derivative of lipoic acid.
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A pharmaceutical composition comprising an active agent that is a reducing agent-choline ester at least one pharmaceutically acceptable excipient.
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A pharmaceutical composition comprising:
- about 0.25% to about 10% of a reducing agent-choline ester,
- optionally, about 0.05% to about 1.0% of a biochemical energy source,
- about 0.25% to about 1% buffer,
- about 0.2% to about 0.6% tonicity agent, and
- about 0.1% to about 0.4% viscosity agent.
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A method for preparing a choline ester comprising:
- providing a reducing agent;
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- reacting the reducing agent with a halogenated choline to yield a choline ester.
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Dependencies are inferred from the claim text.