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US 2022/0151916 A1Published application
Systems and methods for bistable oligomeric machines
OwnerVladik AVETISOV, Roman ILIEVinventors
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Abstract
In some embodiments, molecular and/or oligomeric machines comprising oligomeric modules are selected and joined so as to exhibit conformational bistability wherein a relative orientation between oligomeric modules may change from a first orientation to a second orientation in response to one or more stimuli.
Claims51
An oligomeric machine component configured to exhibit conformational bistability, comprising:
- a first oligomeric module having a first end and a second end;
- a second oligomeric module having a first end and a second end,
- wherein the first end of the first oligomeric module is joined to the first end of the second oligomeric module;
- and
- wherein a relative orientation of the first oligomeric module and the second oligomeric module changes from a first orientation to a second orientation in response to an applied stimulus.
2 more elements
An oligomeric machine, comprising:
- a synthetic material including a first oligomeric module and a second oligomeric module joined to the first oligomeric module to form an oligomeric chain;
- at least one bending or hinge location at a position of co-joinder between the first oligomeric module and the second oligomeric module, the bending or hinge location permitting relative flexure between the first oligomeric module and the second oligomeric module;
- at least one electric generating element;
- a substrate configured relative to the at least one electric generating element and the oligomeric chain such that the relative flexure between the first oligomeric module and the second oligomeric module results in mechanical interaction between at least the second oligomeric module of the oligomeric chain and the at least one electric generating element;
- and
- wherein the oligomeric chain is formed such that in response to a stimulus, the relative flexure occurs between the first oligomeric module and the second oligomeric module in a manner causing the mechanical interaction between the second oligomeric module and the electric generating element, and wherein the mechanical interaction produces a change in electrical voltage associated with the at least one electric generating element.
3 more elements
An oligomeric drug delivery machine, comprising:
- a first oligomeric module;
- a second oligomeric module connected to the first oligomeric module at a bend or hinge location to form an oligomeric chain;
- a therapeutic agent captured between the first oligomeric module and the second oligomeric module;
- wherein the oligomeric chain is configured such that upon application of energy thereto, relative movement occurs between the first oligomeric module and the second oligomeric module such that the captured therapeutic agent is released.
1 more element
An oligomeric machine, comprising:
- an arrangement of molecules configured for introduction into a mammalian body, the molecules being arranged and selected such that when exposed to a prescribed temperature, the arrangement performs at least one mechanical function selected from a group consisting of vibrations, extending, rotating, lifting, pressing, ratcheting, springing, and flexing;
- wherein the prescribed temperature is a normal mammalian body temperature and is below a temperature causing necrosis to mammalian cells, such that upon introduction of the molecular arrangement to the mammalian body, the molecular arrangement does not perform the mechanical function until the arrangement of molecules is exposed to a temperature at least equal to the prescribed temperature.
An oligomeric machine, comprising:
- a synthetic material including a first oligomeric module and a second oligomeric module joined to the first oligomeric module to form an oligomeric chain;
- at least one bend or hinge location at a position of co-joinder between the first oligomeric module and the second oligomeric module, the bend or hinge location permitting relative flexure between the first oligomeric module and the second oligomeric module;
- and
- a first chemical reagent attached to the first oligomeric module;
- a second chemical reagent attached to the second oligomeric module;
- and
- wherein the oligomeric chain is formed such that in response to a prescribed amount of energy applied thereto, the first chemical reagent and the second chemical reagent are caused to be drawn into contact with each other and to undergo a chemical reaction.
4 more elements
An oligomeric machine, comprising:
- a synthetic material including a first oligomeric module and a second oligomeric module joined to the first oligomeric module to form an oligomeric chain;
- at least one bending or hinge location at a position of co-joinder between the first oligomeric module and the second oligomeric module, the bending or hinge location permitting relative flexure between the first oligomeric module and the second oligomeric module;
- at least one piston element;
- a substrate configured relative to the at least one piston element and the oligomeric chain such that the relative flexure between the first oligomeric module and the second oligomeric module results in mechanical interaction between at least the second oligomeric module of the oligomeric chain and the at least one piston element;
- and
- wherein the oligomeric chain is formed such that in response to a prescribed amount of energy applied thereto, the relative flexure occurs between the first oligomeric module and the second oligomeric module in a manner causing the mechanical interaction between the second oligomeric module and the piston element, and wherein the mechanical interaction produces a mechanical force.
3 more elements
Dependencies are inferred from the claim text.