Cancer immunotherapy
AssigneeThe Regents of the University of California
InventorsNicole Steinmetz, Sourabh Shukla
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Abstract
Provided herein is a chimeric Potato virus X (PVX) filament conjugated to a therapeutic agent, a fusogenic peptide or a nucleolin-specific peptide ligand. In one aspect, they additionally comprise encapsulating a nucleic acid. Also provided are methods for use of the compositions diagnostically and therapeutically.
Claims57
A chimeric Potato virus X (PVX) comprising a nucleic acid encapsulated by a plurality of coat proteins, wherein the nucleic acid comprises one or more of:
- a) a non-coding RNA;
- b) an mRNA;
- c) an siRNA;
- or
- d) an miRNA;
- wherein the chimeric PVX homes to the tumor microenvironment (TME) of a B cell malignancy.
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Dependencies are inferred from the claim text.