Near-Infrared-II Nanoparticles and Related Compositions and Methods
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsHongjie Dai, Yeteng Zhong, Zhouran Ma
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Abstract
Provided are cubic-phase (α-phase) erbium (Er)-doped near-infrared-II (NIR-II)-emitting nanoparticles. In certain embodiments, the nanoparticles are near-infrared-IIb (NIR-IIb)-emitting nanoparticles. Also provided are nanoparticles having disposed thereon a layer-by-layer crosslinked polymeric hydrophilic biocompatible coating. Also provided are compositions comprising the nanoparticles of the present disclosure. Methods of using the nanoparticles, e.g., for in vivo imaging, are also provided.
Claims86
A cubic-phase (α-phase) erbium (Er)-doped near-infrared-II (NIR-II, 1000-1700 nm)-emitting nanoparticle.
A nanoparticle having disposed thereon a layer-by-layer crosslinked polymeric hydrophilic biocompatible coating.
Dependencies are inferred from the claim text.