Novel anti-ifnar1 antibodies

An antibody or antigen-binding fragment thereof comprising heavy chain HCDR1, HCDR2 and HCDR3, and/or light chain LCDR1, LCDR2 and LCDR3, wherein

• the HCDR1 comprises SX1WX19N (SEQ ID NO:
• 1) or a homologous sequence of at least 75% sequence identity thereof,
• the HCDR2 comprises KIDPSDSEX2X20X21NQKFX22D (SEQ ID NO:2) or a homologous sequence of at least 75% sequence identity thereof,
• the HCDR3 comprises GGX3IX4X5DYDX6AX7DY (SEQ ID NO:3) or a homologous sequence of at least 60% sequence identity thereof,
• the LCDR1 comprises KX23SEVIYNRLA (SEQ ID NO:4) or a homologous sequence of at least 80% sequence identity thereof,
• the LCDR2 comprises GATX24LEX25 (SEQ ID NO:5) or a homologous sequence of at least 65% sequence identity thereof, and
• the LCDR3 comprises QQYWX8X9PFT (SEQ ID NO:6) or a homologous sequence of at least 65% sequence identity thereof,
• wherein X1 is Y or F, X2 is T or I, X3 is R or G, X4 is S or Y, X5 is F or Y, X6 is A or G, X7 is L or M, X8 is N or S, X9 is K or S, X19 is M or L, X20 is H or R, X21 is F or Y, X22 is R or K, X23 is S or A, X24 is T or S, X25 is S or T, and wherein the antibody or antigen-binding fragment thereof is capable of specifically binding to human interferon alpha receptor 1 (human IFNAR1).