Compound for modulating ddah and adma levels, as well as methods of using thereof to treat disease

A compound defined by the general structure::

• Formula I
• or a pharmaceutically acceptable salt or prodrug thereof, wherein
• represents a single, double, or triple bond;
• X1 and X2, as valence permits, are independently absent or selected from C, CH, CH2, O, CO, S, SO2, and NR;
• wherein R′ is independently selected from hydrogen or C1-C6 alkyl;
• or X1 and X2 together with the bond to which they are attached form a 3 or 4 membered carbocyclic ring;
• R2 is, independently for each occurrence, selected from halogen, cyano, hydroxyl, amino, alkylamino, dialkylamino, alkyl, haloalkyl;
• alkylthio;
• haloalkylthio;
• alkoxy, haloalkoxy, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkylsulfonyl, haloalkylsulfonyl, alkylsulfonyl, haloalkylsulfonyl, alkylcarbonyl, haloalkylcarbonyl, alkoxy carbonyl, haloalkoxy carbonyl, alkylaminocarbonyl, heteroalkylaminocarbonyl, dialkylaminocarbonyl, and heterodialkylaminocarbonyl;
• n is an integer from 0 to 4;
• Y is a structure selected from
• wherein
• Z1 and Z2 are independently S, C, N or O;
• and
• R3, R4, R5, R6, and R7 are independently selected from hydrogen, halogen, cyano, nitro, hydroxyl, amino, alkylamino, dialkylamino, alkyl, haloalkyl;
• alkylthio;
• haloalkylthio;
• alkoxy, haloalkoxy, alkenyl, haloalkenyl, alkynyl, haloalkynyl, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, alkylcarbonyl, haloalkylcarbonyl, alkoxycarbonyl, haloalkoxy carbonyl, with the proviso that when R5 is hydroxyl, at least one of R3, R4, R5, R6, and R7 is not H.