Compositions and methods related to tethered kethoxal derivatives

A kethoxal complex comprising an agent coupled to a kethoxal derivative having a general formula of Formula III:

• wherein E is a click chemistry moiety selected from alkynes, azides, strained alkynes, dienes, dieneophiles, alkoxyamines, carbonyls, phosphines, hydrazides, thiols, and alkenes;
• and A and G are independently selected from H, CF3, CF2H, CFH2, or CH3.

A kethoxal complex comprising an agent coupled to a kethoxal derivative having a general formula of Formula IV:

• wherein A is a substituent selected from H, F, CF3, CF2H, CFH2, or CH3 or is a linker.

A kethoxal complex comprising an agent coupled to a kethoxal derivative having the formula:

• wherein E is a click chemistry moiety selected from alkynes, azides, strained alkynes, dienes, dieneophiles, alkoxyamines, carbonyls, phosphines, hydrazides, thiols, and alkenes;
• and A is independently selected from H, F, CF3, CF2H, CFH2, or CH3.

A kethoxal complex comprising an agent coupled to a kethoxal derivative having the formula:

• wherein A is hydrogen or methyl;
• D is a linker;
• and E is reactive functional group.

A kethoxal derivative of Formula VI

• wherein A is H or methyl, D is a linker or a direct bond;
• and
• wherein E is a substituted or unsubstituted phenol, substituted or unsubstituted thiophenol, substituted or unsubstituted aniline, substituted or unsubstituted tetrazole, substituted or unsubstituted tetrazine, substituted or unsubstituted SPh, substituted or unsubstituted diazirine, substituted or unsubstituted benzophenone, substituted or unsubstituted nitrone, substituted or unsubstituted nitrile oxide, substituted or unsubstituted norbornene, substituted or unsubstituted nitrile, substituted or unsubstituted isocyanide, substituted or unsubstituted quadricyclane, substituted or unsubstituted alkyne, substituted or unsubstituted azide, substituted or unsubstituted strained alkyne, substituted or unsubstituted diene, substituted or unsubstituted dienophile, substituted or unsubstituted alkoxyamine, substituted or unsubstituted carbonyl, substituted or unsubstituted phosphine, substituted or unsubstituted hydrazide, substituted or unsubstituted thiol, or substituted or unsubstituted alkene.