Beta-Carboline Compounds And Use Thereof For The Non-Cytotoxic And Immunological Treatment Of Cancer
AssigneeAc Bioscience
InventorChristian AUCLAIR
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Abstract
The invention provides a β-carboline compound (an indole-containing compound) able to induce actin network remodeling in cancer cells into actin organized network and use thereof in non-cytotoxic cancer immunotherapy, for enhancing immune checkpoint inhibitor therapy, for activating cancer immune response, for treating or lessening the symptoms of, or preventing the human cancer, alone or in combination with one or more cancer immunotherapeutic agent for simultaneous, separate or sequential administration.
Claims21
A pharmaceutical combination of a β-carboline compound able to induce actin network remodelling in cancer cells into actin organized network and one or more cancer immunotherapeutic agent for simultaneous, separate or sequential administration,
- wherein the β-carboline compound fulfils the following criteria:
- when malignant fibroblasts (E/F) extract is grown in presence of the β-carboline compound, the dynamics of actin polymerization displays similar parameters (rate constant and plateau value) as observed in non-malignant fibroblasts, and the malignant fibroblasts (E/F) recover cell-cell adhesion properties and self-organize in clusters as occurring with non-malignant fibroblasts,
- and wherein the cancer immunotherapeutic agent is selected from the group consisting of immune checkpoint inhibitor, TCR-T cells, CAR-T cells and a combination thereof.
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A method of activating a cancer immune response, comprising administering to a subject in need thereof a therapeutically effective amount of a β-carboline compound able to induce actin network remodelling in cancer cells into actin organized network, wherein the β-carboline compound fulfils the following criteria:
- when malignant fibroblasts (E/F) extract is grown in presence of the β-carboline compound, the dynamics of actin polymerization displays similar parameters (rate constant and plateau value) as observed in non-malignant fibroblasts, and the malignant fibroblasts (E/F) recover cell-cell adhesion properties and self-organize in clusters as occurring with non-malignant fibroblasts.
A non-cytotoxic method of treating or lessening the symptoms of human cancer, or preventing human cancer progression, comprising administering to a subject in need thereof a therapeutically effective amount of a β-carboline compound able to induce actin network remodelling in cancer cells into actin organized network, wherein the β-carboline compound fulfils the following criteria:
- when malignant fibroblasts (E/F) extract is grown in presence of the β-carboline compound-, the dynamics of actin polymerization displays similar parameters (rate constant and plateau value) as observed in non-malignant fibroblasts, and the malignant fibroblasts (E/F) recover cell-cell adhesion properties and self-organize in clusters as occurring with non-malignant fibroblasts.
Dependencies are inferred from the claim text.