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US 2022/0136029 A1Published application
Biotechnological optimization of microorganisms for the 1,2-dehydrogenation of steroids
AssigneeSanofi
InventorsClaus Tobias LATTEMANN, Bernd JANOCHA, Hans-Falk RASSER, Sebastian RISSOM
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Abstract
The present invention concerns a genetically modified bacterium and to its industrial application, in particular in the 1,2-dehydrogenation of steroids.
Claims16
A genetically modified bacterium wherein expression of a gene coding a 20-beta-hydroxysteroid dehydrogenase (20β-HSDH) is reduced or suppressed compared to a corresponding unmodified bacterium, wherein the corresponding unmodified bacterium has Δ1-dehydrogenase activity and 20-β-dehydrogenase activity.
Dependencies are inferred from the claim text.