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US 2022/0135963 A1Published application
Targeted rna editing by leveraging endogenous adar using engineered rnas
AssigneePeking University
InventorsWensheng WEI, Zongyi YI, Liang QU, Feng TIAN, Chunhui WANG, Shiyou ZHU, Zhuo ZHOU
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Abstract
Provided are methods for editing RNA by introducing a deaminase-recruiting RNA in a host cell for deamination of an adenosine in a target RNA, deaminase-recruiting RNAs used in the RNA editing methods, compositions and kits comprising the same.
Claims25
A method for editing a target RNA in a host cell, comprising introducing a deaminase-recruiting RNA (dRNA) or a construct comprising a nucleic acid encoding the dRNA into the host cell, wherein:
- (1) the dRNA comprises a targeting RNA sequence that is at least partially complementary to the target RNA,
- (2) the dRNA is capable of recruiting an adenosine deaminase acting on RNA (ADAR), and
- (3) the dRNA is a circular RNA or capable of forming a circular RNA.
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Dependencies are inferred from the claim text.