US 2022/0135574 A1 · BIARYL DERIVATIVE AS GPR120 AGONIST

Abstract

The present invention relates to a biaryl derivative expressed by the chemical formula 1, a method for producing the biaryl derivative, a pharmaceutical composition comprising same, and use of same, the biaryl derivative expressed by the chemical formula 1, as a GPR120 agonist, promoting GLP-1 generation in the gastro-intestinal tract, reducing insulin resistance in the liver, muscles and the like from anti-inflammatory activity in the macrophage, pancreatic cells and the like, and allowing effective use in prevention or treatment of inflammation or metabolic diseases such as diabetes, complications from diabetes, obesity, non-alcoholic fatty liver disease, fatty liver disease, and osteoporosis.

A compound selected from the group consisting of:

3-[6-(2-isopropylsulfanyl-pyridin-3-yl)-quinolin-2-yl]-propionic acid,
3-[6-(6-isopropylsulfanyl-pyridin-2-yl)-quinolin-2-yl]-propionic acid,
[6-(6-cyclopentyloxy-pyridin-2-yl)-naphthalen-2-yloxy]-acetic acid,
[6-(2-cyclopentyloxy-pyridin-3-yl)-naphthalen-2-yloxy]-acetic acid,
4-[6-(2-isopropylsulfanyl-pyridin-3-yl)-naphthalen-2-yloxy]-butyric acid,
4-[6-(6-isopropylsulfanyl-pyridin-2-yl)-naphthalen-2-yloxy]-butyric acid,
3-[6-(2-isopropylsulfanyl-pyridin-3-yl)-chroman-2-yl]-propionic acid,
3-[6-(6-isopropylsulfanyl-pyridin-2-yl)-chroman-2-yl]-propionic acid,
3-[6-(6-cyclopentyloxy-pyridin-2-yl)-chroman-2-yl]-propionic acid,
3-[6-(2-cyclopentyloxy-pyridin-3-yl)-chroman-2-yl]-propionic acid,
3-[6-(6-cyclopentyloxy-pyridin-2-yl)-1,2,3,4-tetrahydro-quinolin-2-yl]-propionic acid,
3-[6-(6-cyclopentyloxy-pyridin-2-yl)-1-methyl-1,2,3,4-tetrahydro-quinolin-2-yl]-propionic acid,
[6-(2-isopropylsulfanyl-pyridin-3-yl)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid,
[6-(6-isopropylsulfanyl-pyridin-2-yl)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid,
3-[6-(2-cyclopentyloxy-pyridin-3-yl)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-propionic acid,
3-[6-(2-isopropylsulfanyl-pyridin-3-yl)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-propionic acid,
4-(3′-benzyloxy-3,5-difluoro-biphenyl-4-yloxy)-butyric acid,
4-(3,5-difluoro-3′-isopropoxy-biphenyl-4-yloxy)-butyric acid,
4-(3,5-difluoro-3′-propoxy-biphenyl-4-yloxy)-butyric acid,
4-(3′-cyclopropylmethoxy-3,5-difluoro-biphenyl-4-yloxy)-butyric acid,
4-(3′-cyclobutoxy-3,5-difluoro-biphenyl-4-yloxy)-butyric acid,
4-[4-(2,2-dimethyl-2,3-dihydro-benzofuran-7-yl)-2,6-difluoro-phenoxy]-butyric acid,
4-[4-(2,2-dimethyl-benzo[1,3]dioxol-4-yl)-2,6-difluoro-phenoxy]-butyric acid,
4-[4-(2-cyclobutylsulfanyl-3-pyridyl)-2,6-difluoro-phenoxy]butanenitrile,
2-cyclobutylsulfanyl-3-{3,5-difluoro-4-[3-(1H-tetrazol-5-yl)propoxy]phenyl}pyridine,
2-cyclobutylsulfanyl-3-{4-[3-(1H-tetrazol-5-yl)propyl]phenyl}pyridine,
5-[4-(2-cyclobutylsulfanyl-3-pyridyl)phenyl]pentanoic acid,
5-[4-(6-cyclopentylsulfanyl-2-pyridyl)phenyl]pentanoic acid,
5-[4-(2-cyclopentylsulfanyl-3-pyridyl)phenyl]pentanoic acid,
2-cyclobutylsulfanyl-3-[3,5-difluoro-4-(1H-tetrazol-5-ylmethoxy)phenyl]pyridine,
5-[2,6-difluoro-4-(2-propylsulfanyl-3-pyridyl)phenyl]pentanoic acid,
5-[4-(6-cyclobutoxy-2-pyridyl)-2,6-difluoro-phenyl]pentanoic acid,
5-[4-(6-cyclopentoxy-2-pyridyl)-2,6-difluoro-phenyl]pentanoic acid,
5-[4-(2,2-difluoro-benzo[1,3]dioxol-4-yl)-2,6-difluoro-phenyl]pentanoic acid,
5-[4-(2-cyclobutylsulfanyl-3-pyridyl)-2,6-difluoro-phenyl]pentanoic acid,
5-[4-(2-cyclopentylsulfanyl-3-pyridyl)-2,6-difluoro-phenyl]pentanoic acid,
5-[4-(2-cyclopentoxy-3-pyridyl)-2,6-difluoro-phenyl]pentanoic acid,
{2-[4-(2-cyclobutylsulfanyl-3-pyridyl)-2,6-difluoro-phenyl]ethoxy}acetic acid,
5-[4-(2-cyclobutylsulfanyl-3-pyridyl)phenyl]hexanoic acid,
5-[4-(6-cyclobutoxy-2-pyridyl)-phenyl]hexanoic acid,
5-[4-(6-cyclobutoxy-2-pyridyl)-2,6-difluoro-phenyl]hexanoic acid,
5-[4-(2-ethylsulfanyl-3-pyridyl)-2,6-difluoro-phenyl]hexanoic acid,
5-[2,6-difluoro-4-(2-propylsulfanyl-3-pyridyl)-phenyl]hexanoic acid,
4-[1-methyl-5-(2-phenoxyphenyl)benzimidazol-2-yl]butanoic acid,
3-[1-methyl-5-(2-phenoxyphenyl)benzimidazol-2-yl]propanoic acid,
5-[2,6-difluoro-4-(2-isopropoxy-3-pyridyl)phenyl]hexanoic acid,
5-(2′-cyclopentylamino-3,5-difluoro-bisphenyl-4-yl)hexanoic acid,
5-[4-(2-cyclobutylsulfanyl-3-pyridyl)-2,6-difluoro-phenyl]hexanoic acid,
5-[4-(2-cyclopentylsulfanyl-3-pyridyl)-2,6-difluoro-phenyl]hexanoic acid,
5-[2,6-difluoro-4-(2-isopropylsulfanyl-3-pyridyl)-phenyl]hexanoic acid,
5-[4-(2-cyclopentoxy-3-pyridyl)-2,6-difluoro-phenyl]hexanoic acid,
5-(3′-cyclopentylamino-3,5-difluoro-biphenyl-4-yl)-hexanoic acid,
5-[2,6-difluoro-4-(6-isopropylsulfanyl-2-pyridyl)-phenyl]hexanoic acid,
5-[4-(6-cyclopentylsulfanyl-2-pyridyl)-2,6-difluoro-phenyl]hexanoic acid,
5-[2,6-difluoro-4-(6-propylsulfanyl-2-pyridyl)phenyl]hexanoic acid,
5-[4-(6-cyclopentoxy-2-pyridyl)-2,6-difluoro-phenyl]hexanoic acid,
4-[4-(2-isopropoxy-3-pyridyl)phenyl]butanoic acid,
5-[2,6-difluoro-4-(2-hydroxy-3-pyridyl)phenyl]hexanoic acid,
5-[4-(2-cyclobutoxy-3-pyridyl)-2,6-difluoro-phenyl]hexanoic acid,
5-[4-(2-cyclopropylmethoxy-3-pyridyl)-2,6-difluoro-phenyl]hexanoic acid,
5-[[4-(2-cyclobutylsulfanyl-3-pyridyl)-2,6-difluoro-phenoxy]methyl]isoxazol-3-ol,
N′-hydroxy-4-[4-(2-propylsulfanyl-3-pyridyl)phenyl]butaneamidine,
3-[3-[4-(2-propylsulfanyl-3-pyridyl)phenyl]propyl]-4H-1,2,4-oxadiazol-5-one,
3-[3-[4-(2-propylsulfanyl-3-pyridyl)phenyl]propyl]-4H-1,2,4-oxadiazol-5-thione,
5-[[4-(2-cyclopentylsulfanyl-3-pyridyl)-2,6-difluoro-phenoxy]methyl]isoxazol-3-ol,
5-[[2,6-difluoro-4-(2-propylsulfanyl-3-pyridyl)phenoxy]methyl]isoxazol-3-ol,
5-[[4-[2-(cyclopentoxy)-3-pyridyl]-2,6-difluoro-phenoxy]methyl]isoxazol-3-ol,
5-[[2,6-difluoro-4-(2-isopropylsulfanyl-3-pyridyl)phenoxy]methyl]isoxazol-3-ol,
5-[[2,6-difluoro-4-(2-isopropoxy-3-pyridyl)phenoxy]methyl]isoxazol-3-ol,
5-[[2,6-difluoro-4-(6-isopropylsulfanyl-2-pyridyl)phenoxy]methyl]isoxazol-3-ol,
5-[[2,6-difluoro-4-(6-isopropoxy-2-pyridyl)phenoxy]methyl]isoxazol-3-ol,
5-[[4-[6-(cyclopropylmethoxy)-2-pyridyl]-2,6-difluoro-phenoxy]methyl]isoxazol-3-ol,
5-[[2,6-difluoro-4-(6-propoxy-2-pyridyl)phenoxy]methyl]isoxazol-3-ol,
5-[[2,6-difluoro-4-(2-propoxy-3-pyridyl)phenoxy]methyl]isoxazol-3-ol,
5-[(E)-3-[4-(2-cyclobutylsulfanyl-3-pyridyl)-2,6-difluoro-phenyl]allyl]thiazolidin-2,4-dione,
5-[[4-[2-(cyclobutoxy)-3-pyridyl]-2,6-difluoro-phenoxy]methyl]isoxazol-3-ol,
5-[[4-[2-(cyclobutylmethoxy)-3-pyridyl]-2,6-difluoro-phenoxy]methyl]isoxazol-3-ol,
5-[[4-[2-(cyclopentoxy)-3-pyridyl]anilino]methyl]isoxazol-3-ol,
5-[[4-[2-(cyclopentoxy)-3-pyridyl]-2,6-difluoro-phenoxy]methyl]pyridin-2-ol,
4-[[4-[2-(cyclopentoxy)-3-pyridyl]-2,6-difluoro-phenoxy]methyl]pyridin-2-ol,
5-[[4-[2-(cyclopentoxy)-3-pyridyl]phenyl]sulfanylmethyl]isoxazol-3-ol,
5-[(E)-3-[4-[2-(cyclopentoxy)-3-pyridyl]-2,6-difluoro-phenyl]allyl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one,
5-[[4-[2-(cyclopentoxy)-3-pyridyl]-2,6-difluoro-phenyl]sulfanylmethyl]isoxazol-3-ol,
5-[[4-[2-(cyclopentoxy)-3-pyridyl]-2,6-difluoro-anilino]methyl]isoxazol-3-ol,
5-[3-[4-[2-(cyclopentoxy)-3-pyridyl]-2,6-difluoro-phenyl]propyl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one,
5-[[4-[2-(cyclopentoxy)-3-pyridyl]-N-methyl-anilino]methyl]isoxazol-3-ol,
5-[2-[4-[2-(cyclopentoxy)-3-pyridyl]-2,6-difluoro-phenyl]ethyl]isoxazol-3-ol,
5-[2-[4-[2-(cyclopentoxy)-3-pyridyl]-2,6-difluoro-phenyl]propyl]isoxazol-3-ol,
5-[2-[4-[2-(cyclopentoxy)-3-pyridyl]-2,6-difluoro-phenoxy]ethyl]isoxazol-3-ol,
5-[2-[4-[2-(cyclopentoxy)-3-pyridyl]-2,6-difluoro-anilino]ethyl]isoxazol-3-ol,
2-[1-[5-(6-isopropylsulfanyl-2-pyridyl)-2-pyridyl]-3-piperidyl]acetic acid,
4-[[5-(6-isopropylsulfanyl-2-pyridyl)-2-pyridyl]amino]butanoic acid,
2-[1-[4-(2-cyclobutylsulfanyl-3-pyridyl)phenyl]pyrazol-4-yl]acetic acid,
5-[4-[2-(cyclopentoxy)-3-pyridyl]-2,6-difluoro-anilino]pentanoic acid,
5-[4-[2-(cyclopentoxy)-3-pyridyl]-N-ethyl-2,6-difluoro-anilino]pentanoic acid,
5-[2,6-difluoro-4-(6-isopropylsulfanyl-2-pyridyl)anilino]pentanoic acid,
5-[2,6-difluoro-4-(2-isopropylsulfanyl-3-pyridyl)anilino]pentanoic acid,
5-[4-[6-(cyclopropylmethoxy)-2-pyridyl]-2,6-difluoro-anilino]pentanoic acid,
5-[4-[2-(cyclopropylmethoxy)-3-pyridyl]-2,6-difluoro-anilino]pentanoic acid,
2-[1-[4-(2-cyclopentylsulfanyl-3-pyridyl)-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
5-[4-[6-(cyclopropylmethoxy)-2-pyridyl]-2,6-difluoro-N-methyl-anilino]pentanoic acid,
2-[1-[4-[2-(cyclopentoxy)-3-pyridyl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[2,6-difluoro-4-(2-tetrahydrofuran-3-yloxy-3-pyridyl)phenyl]-4-piperidyl]acetic acid,
2-[1-[2,6-difluoro-4-(2-isopropylsulfanyl-3-pyridyl)phenyl]-4-piperidyl]acetic acid,
2-[1-[2,6-difluoro-4-(6-isopropylsulfanyl-2-pyridyl)phenyl]-4-piperidyl]acetic acid,
2-[1-[4-[6-(cyclopropylmethoxy)-2-pyridyl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[2,6-difluoro-4-(6-isopropylsulfanyl-2-pyridyl)phenyl]-3-piperidyl]acetic acid,
2-[1-[2,6-difluoro-4-(2-isopropylsulfanyl-3-pyridyl)phenyl]-3-piperidyl]acetic acid,
2-[1-[2,6-difluoro-4-(2-isopropylsulfanyl-3-pyridyl)phenyl]azetidin-3-yl]acetic acid,
6-[2,6-difluoro-4-(2-isopropylsulfanyl-3-pyridyl)phenyl]-6-azaspiro[2.5]octan-2-carboxylic acid,
6-[2,6-difluoro-4-(6-isopropylsulfanyl-2-pyridyl)phenyl]-6-azaspiro[2.5]octan-2-carboxylic acid,
2-[1-[4-(2-cyclopentylsulfanyl-3-pyridyl)-2,6-difluoro-phenyl]azetidin-3-yl]acetic acid,
2-[1-[4-[2-(cyclopentoxy)-3-pyridyl]-2,6-difluoro-phenyl]azetidin-3-yl]acetic acid,
2-[1-[2,6-difluoro-4-(6-isopropylsulfanyl-2-pyridyl)phenyl]azetidin-3-yl]acetic acid,
2-[1-[2,6-difluoro-4-(6-isopropoxy-2-pyridyl)phenyl]azetidin-3-yl]acetic acid,
2-[1-[4-[6-(cyclopentoxy)-2-pyridyl]-2,6-difluoro-phenyl]azetidin-3-yl]acetic acid,
2-[1-[2,6-difluoro-4-(2-propylsulfanyl-3-pyridyl)phenyl]-4-piperidyl]acetic acid,
2-[1-[4-(2-cyclobutylsulfanyl-3-pyridyl)-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[2,6-difluoro-4-(2-isopropoxy-3-pyridyl)phenyl]-4-piperidyl]acetic acid,
2-[1-[2,6-difluoro-4-(2-propoxy-3-pyridyl)phenyl]-4-piperidyl]acetic acid,
2-[1-[4-[2-(cyclopropylmethoxy)-3-pyridyl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[2,6-difluoro-4-(2-isopropylsulfanyl-3-pyridyl)phenyl]pyrazol-4-yl]acetic acid,
2-[1-[2,6-difluoro-4-(6-isopropylsulfanyl-2-pyridyl)phenyl]pyrazol-4-yl]acetic acid,
2-[1-[2,6-difluoro-4-(2-isopropylsulfanyl-3-pyridyl)phenyl]pyrrolidin-3-yl]acetic acid,
2-[1-[2,6-difluoro-4-(6-isopropylsulfanyl-2-pyridyl)phenyl]pyrrolidin-3-yl]acetic acid,
3-[1-[2,6-difluoro-4-(2-isopropylsulfanyl-3-pyridyl)phenyl]-4-piperidyl]propanoic acid,
3-[1-[2,6-difluoro-4-(6-isopropylsulfanyl-2-pyridyl)phenyl]-4-piperidyl]propanoic acid,
2-[2-[4-(2-cyclopentylsulfanyl-3-pyridyl)-2,6-difluoro-anilino]ethyl]cyclopropane carboxylic acid,
2-[1-[2,6-difluoro-4-(2-isopropylsulfanyl-3-pyridyl)phenyl]-3-piperidyl]acetamide,
2-[4-[2,6-difluoro-4-(2-isopropylsulfanyl-3-pyridyl)phenyl]piperazin-1-yl]acetic acid,
3-[1-[2,6-difluoro-4-(2-isopropylsulfanyl-3-pyridyl)phenyl]pyrazol-4-yl]propanoic acid,
4-[5-(2-cyclopentylsulfanyl-3-pyridyl)indolin-1-yl]butanoic acid,
3-[1-[2,6-difluoro-4-(2-isopropylsulfanyl-3-pyridyl)phenyl]azetidin-3-yl]propanoic acid,
2-[(3R)-1-[2,6-difluoro-4-(2-isopropylsulfanyl-3-pyridyl)phenyl]pyrrolidin-3-yl]acetic acid,
2-[(3R)-1-[4-[2-(cyclopentoxy)-3-pyridyl]-2,6-difluoro-phenyl]pyrrolidin-3-yl]acetic acid,
2-[(3S)-1-[2,6-difluoro-4-(2-isopropylsulfanyl-3-pyridyl)phenyl]pyrrolidin-3-yl]acetic acid,
2-[(3S)-1-[4-[2-(cyclopentoxy)-3-pyridyl]-2,6-difluoro-phenyl]pyrrolidin-3-yl]acetic acid,
2-[1-[2-fluoro-4-(2-isopropylsulfanyl-3-pyridyl)phenyl]-4-piperidyl]acetic acid,
2-[1-[4-[2-(cyclopentoxy)-3-pyridyl]-2-fluoro-phenyl]-4-piperidyl]acetic acid,
3-[6-(6-isopropylsulfanyl-pyridin-2-yl)-naphthalen-2-yl]-propanoic acid,
3-[6-(6-phenoxy-pyridin-2-yl)-naphthalen-2-yl]-propanoic acid,
3-[6-(2-phenoxy-phenyl)-naphthalen-2-yl]-propanoic acid,
3-[6-(6-cyclopentylsulfanyl-pyridin-2-yl)-naphthalen-2-yl]-propanoic acid,
3-[6-(2-phenoxy-pyridin-3-yl)-naphthalen-2-yl]-propanoic acid,
3-[6-(3-phenoxy-phenyl)-naphthalen-2-yl]-propanoic acid,
3-[6-(3-isopropoxy-phenyl)-naphthalen-2-yl]-propanoic acid,
3-[6-(3-cyclobutoxy-phenyl)-naphthalen-2-yl]-propanoic acid,
3-[6-(6-cyclobutoxy-pyridin-2-yl)-naphthalen-2-yl]-propanoic acid,
3-[6-(2-isopropoxy-pyridin-3-yl)-naphthalen-2-yl]-propanoic acid,
3-[6-(2-cyclopentyloxy-pyridin-3-yl)-naphthalen-2-yl]-propanoic acid,
3-{6-[2-(2-fluoro-phenoxy)-phenyl]-naphthalen-2-yl}-propanoic acid,
3-{6-[6-(2-fluoro-phenoxy)-pyridin-2-yl]-naphthalen-2-yl}-propanoic acid,
4-[4-(2,2-difluoro-benzo[1,3]dioxol-4-yl)-2,6-difluoro-phenylsulfanyl]-butyric acid,
4-[4-(2,2-difluoro-benzo[1,3]dioxol-4-yl)-2-fluoro-phenylsulfanyl]-butyric acid,
4-[4-(2,2-difluoro-benzo[1,3]dioxol-4-yl)-phenylsulfanyl]-butyric acid,
4-(4-spiro[1,3-benzodioxol-2,1′-cyclopentan]-4-ylphenyl)sulfanylbutanoic acid,
4-(2-fluoro-4-spiro[1,3-benzodioxol-2,1′-cyclopentan]-4-yl-phenyl)sulfanylbutanoic acid,
5-[4-(2-isopropoxy-pyridin-3-yl)-phenyl]-5-methyl-hexanoic acid,
5-[4-(2-isopropylsulfanyl-pyridin-3-yl)-phenyl]-5-methyl-hexanoic acid,
5-[4-(2-cyclopentyloxy-pyridin-3-yl)-phenyl]-5-methyl-hexanoic acid,
5-[4-(2-cyclopentyloxy-pyridin-3-yl)-2-fluoro-phenyl]-5-methyl-hexanoic acid,
5-[4-(2-cyclopentyloxy-pyridin-3-yl)-2,6-difluoro-phenyl]-5-methyl-hexanoic acid,
5-[4-(2-cyclopentylsulfanyl-pyridin-3-yl)-phenyl]-5-methyl-hexanoic acid,
5-[4-(2-cyclobutylsulfanyl-pyridin-3-yl)-2,6-difluoro-phenyl]-5-methyl-hexanoic acid,
5-[4-(2-cyclobutylsulfanyl-pyridin-3-yl)-phenyl]-5-methyl-hexanoic acid,
4-{1-[4-(2-cyclopentyloxy-pyridin-3-yl)-2,6-difluoro-phenyl]-cyclopropyl}-butyric acid,
4-{1-[4-(2-cyclobutylsulfanyl-pyridin-3-yl)-2,6-difluoro-phenyl]-cyclopropyl}-butyric acid,
4-{1-[4-(6-cyclobutoxy-pyridin-2-yl)-2,6-difluoro-phenyl]-cyclopropyl}-butyric acid,
4-{1-[4-(2-cyclobutylmethoxy-pyridin-3-yl)-2,6-difluoro-phenyl]-cyclopropyl}-butyric acid,
4-{1-[4-(6-cyclopropylmethoxy-pyridin-2-yl)-2,6-difluoro-phenyl]-cyclopropyl}-butyric acid,
5-[4-(2,2-difluoro-benzo[1,3]dioxol-4-yl)-2,6-difluoro-phenyl]-hexanoic acid,
{2-[4-(2-cyclopentyloxy-pyridin-3-yl)-phenyl]-2,2-difluoro-ethoxy}-acetic acid,
{2-[4-(2-cyclobutylsulfanyl-pyridin-3-yl)-phenyl]-2,2-difluoro-ethoxy}-acetic acid,
{2-[4-(6-cyclobutoxy-pyridin-2-yl)-phenyl]-2,2-difluoro-ethoxy}-acetic acid,
3-{2-[4-(2-cyclopentyloxy-pyridin-3-yl)-2,6-difluoro-phenyl]-cyclopropyl}-propanoic acid,
3-{2-[4-(2-cyclobutylsulfanyl-pyridin-3-yl)-2,6-difluoro-phenyl]-cyclopropyl}-propanoic acid,
5-[4-(2-cyclopentyloxy-pyridin-3-yl)-phenyl]-5,5-difluoro-pentanoic acid,
5-[4-(2-cyclobutylsulfanyl-pyridin-3-yl)-phenyl]-5,5-difluoro-pentanoic acid,
3-{2-[2,6-difluoro-4-(2-propylsulfanyl-pyridin-3-yl)-phenyl]-cyclopropyl}-propanoic acid,
3-{2-[4-(6-cyclobutoxy-pyridin-2-yl)-2,6-difluoro-phenyl]-cyclopropyl}-propanoic acid,
5-[4-(2-cyclopropylmethoxy-pyridin-3-yl)-phenyl]-5,5-difluoro-pentanoic acid,
3-{2-[4-(2-cyclopentylsulfanyl-pyridin-3-yl)-2,6-difluoro-phenyl]-cyclopropyl}-propanoic acid,
3-{2-[4-(2-cyclopentylamino-pyridin-3-yl)-2,6-difluoro-phenyl]-cyclopropyl}-propanoic acid,
5-[4-(2-cyclopentylsulfanyl-pyridin-3-yl)-phenyl]-5,5-difluoro-pentanoic acid,
5-[4-(2-cyclobutoxy-pyridin-3-yl)-phenyl]-5,5-difluoro-pentanoic acid,
5-[4-(6-cyclobutoxy-pyridin-2-yl)-phenyl]-5,5-difluoro-pentanoic acid,
{4-[4-(2-cyclopentyloxy-pyridin-3-yl)-2-fluoro-phenyl]-cyclohexyl}-acetic acid,
3-{2-[4-(2-cyclobutoxy-pyridin-3-yl)-2,6-difluoro-phenyl]-cyclopropyl}-propanoic acid,
3-{2-[4-(2-cyclobutylmethoxy-pyridin-3-yl)-2,6-difluoro-phenyl]-cyclopropyl}-propanoic acid,
3-(2-{2,6-difluoro-4-[2-(tetrahydro-pyran-4-yloxy)-pyridin-3-yl]-phenyl}-cyclopropyl)-propanoic acid,
3-{2-[4-(6-cyclopropylmethoxy-pyridin-2-yl)-2,6-difluoro-phenyl]-cyclopropyl}-propanoic acid,
5,5-difluoro-5-[4-(6-isopropylsulfanyl-pyridin-2-yl)-phenyl]-pentanoic acid,
4-[4-(2,2-dimethyl-2,3-dihydro-benzofuran-4-yl)-phenoxy]-butyric acid,
4-[4-(2,2-dimethyl-2,3-dihydro-benzofuran-4-yl)-2-fluoro-phenoxy]-butyric acid,
4-{[4-(2-cyclobutylsulfanyl-pyridin-3-yl)-2,6-difluoro-phenyl]-methyl-amino}-butyric acid,
4-{[4-(2-cyclopentyloxy-pyridin-3-yl)-2,6-difluoro-phenyl]-methyl-amino}-butyric acid,
4-{[4-(2-cyclopentylsulfanyl-pyridin-3-yl)-2,6-difluoro-phenyl]-methyl-amino}-butyric acid,
4-{[2,6-difluoro-4-(2-isopropylsulfanyl-pyridin-3-yl)-phenyl]-methyl-amino}-butyric acid,
4-[(3′-cyclobutoxy-3,5-difluoro-biphenyl-4-yl)-methyl-amino]-butyric acid,
4-[5-(2-cyclopentylsulfanyl-pyridin-3-yl)-indol-1-yl]-butyric acid,
4-[(3,5-difluoro-3′-pyrrolidin-1-yl-biphenyl-4-yl)-methyl-amino]-butyric acid,
4-{[4-(6-cyclobutylsulfanyl-pyridin-2-yl)-2,6-difluoro-phenyl]-methyl-amino}-butyric acid,
4-{[4-(2,2-difluoro-benzo[1,3]dioxol-4-yl)-2,6-difluoro-phenyl]-methyl-amino}-butyric acid,
4-{[4-(6-cyclopentyloxy-pyridin-2-yl)-2,6-difluoro-phenyl]-methyl-amino}-butyric acid,
4-{[4-(6-cyclobutoxy-pyridin-2-yl)-2,6-difluoro-phenyl]-methyl-amino}-butyric acid,
4-{[4-(2-cyclobutoxy-pyridin-3-yl)-2,6-difluoro-phenyl]-methyl-amino}-butyric acid,
4-{[2,6-difluoro-4-(2-propylsulfanyl-pyridin-3-yl)-phenyl]-methyl-amino}-butyric acid,
4-{[4-(2-ethylsulfanyl-pyridin-3-yl)-2,6-difluoro-phenyl]-methyl-amino}-butyric acid,
4-{[4-(2-cyclobutylsulfanyl-pyridin-3-yl)-2-fluoro-phenyl]-methyl-amino}-butyric acid,
2-{[4-(2-cyclopentylsulfanyl-pyridin-3-yl)-2,6-difluoro-phenylamino]-methyl}-cyclopropane carboxylic acid,
2-{[4-(2-cyclopentylsulfanyl-pyridin-3-yl)-phenylamino]-methyl}-cyclopropane carboxylic acid,
4-{[2-fluoro-4-(2-isopropylsulfanyl-pyridin-3-yl)-phenyl]-methyl-amino}-butyric acid,
4-{[4-(2-cyclopentylsulfanyl-pyridin-3-yl)-2-fluoro-phenyl]-methyl-amino}-butyric acid,
4-{[2,6-difluoro-4-(2-isopropoxy-pyridin-3-yl)-phenyl]-methyl-amino}-butyric acid,
4-[(2′-cyclopentylamino-3,5-difluoro-biphenyl-4-yl)-methyl-amino]-butyric acid,
4-[methyl-(3,5,5′-trifluoro-2′-isopropoxy-biphenyl-4-yl)-amino]-butyric acid,
4-{[4-(2-cyclopentyloxy-5-methyl-pyridin-3-yl)-2,6-difluoro-phenyl]-methyl-amino}-butyric acid,
4-{[4-(2-cyclobutylmethoxy-pyridin-3-yl)-2,6-difluoro-phenyl]-methyl-amino}-butyric acid,
4-{[2,6-difluoro-4-(2-methoxy-pyridin-3-yl)-phenyl]-methyl-amino}-butyric acid,
4-({2,6-difluoro-4-[2-(tetrahydro-furan-3-yloxy)-pyridin-3-yl]-phenyl}-methyl-amino)-butyric acid,
4-[(3,5-difluoro-2′-pyrrolidin-1-yl-biphenyl-4-yl)-methyl-amino]-butyric acid,
4-[(3,5-difluoro-2′-methylamino-biphenyl-4-yl)-methyl-amino]-butyric acid,
4-{[3,5-difluoro-2′-(isopropyl-methyl-amino)-biphenyl-4-yl]-methyl-amino}-butyric acid,
4-{[4-(2-cyclobutylsulfanyl-pyridin-3-yl)-2,6-difluoro-phenyl]-ethyl-amino}-butyric acid,
4-{[4-(2-cyclobutylmethoxy-pyridin-3-yl)-2,6-difluoro-phenyl]-ethyl-amino}-butyric acid,
4-{[2,6-difluoro-4-(2-isopropoxy-pyridin-3-yl)-phenyl]-ethyl-amino}-butyric acid,
(R)-5-[4-(2-cyclobutylsulfanyl-pyridin-3-yl)-2,6-difluoro-phenyl]-hexanoic acid,
(E)-(R)-5-[4-(2-cyclobutylsulfanyl-pyridin-3-yl)-2,6-difluoro-phenyl]-hex-2-enoic acid,
(S)-5-[4-(2-cyclobutylsulfanyl-pyridin-3-yl)-2,6-difluoro-phenyl]-hexanoic acid,
5-{2,6-difluoro-4-[2-(tetrahydro-furan-3-yloxy)-pyridin-3-yl]-phenyl}-hexanoic acid,
5-{2,6-difluoro-4-[2-(tetrahydro-pyran-4-yloxy)-pyridin-3-yl]-phenyl}-hexanoic acid,
5-{2,6-difluoro-4-[2-(oxetan-3-yloxy)-pyridin-3-yl]-phenyl}-hexanoic acid,
4-[4-(2-cyclobutoxy-pyridin-3-yl)-2-fluoro-phenoxy]-butyric acid,
4-[4-(2-cyclopentyloxy-pyridin-3-yl)-2-fluoro-phenoxy]-butyric acid,
4-[4-(2-cyclobutylsulfanyl-pyridin-3-yl)-2-fluoro-phenoxy]-butyric acid,
4-[4-(2-cyclopentylsulfanyl-pyridin-3-yl)-2-fluoro-phenoxy]-butyric acid,
6-[4-(2-cyclopentyloxy-pyridin-3-yl)-2,6-difluoro-phenyl]-heptanoic acid,
6-[4-(2-cyclopentylsulfanyl-pyridin-3-yl)-2,6-difluoro-phenyl]-heptanoic acid,
4-[4-(2-cyclopropylmethoxy-pyridin-3-yl)-2-fluoro-phenylsulfanyl]-butyric acid,
4-[4-(2-cyclopropylmethoxy-pyridin-3-yl)-2-fluoro-phenoxy]-butyric acid,
4-[4-(2-cyclobutylmethoxy-pyridin-3-yl)-2-fluoro-phenoxy]-butyric acid,
4-[3-(6-cyclopentyloxy-pyridin-2-yl)-phenoxy]-butyric acid,
4-[3-(2-cyclopentyloxy-pyridin-3-yl)-phenoxy]-butyric acid,
5-[4-(2-cyclopentyloxy-pyridin-3-yl)-2-fluoro-phenyl]-pentanoic acid,
5-[4-(2-cyclobutoxy-pyridin-3-yl)-2-fluoro-phenyl]-pentanoic acid,
5-[4-(2-cyclobutylmethoxy-pyridin-3-yl)-2-fluoro-phenyl]-pentanoic acid,
5-[4-(2-cyclopropylmethoxy-pyridin-3-yl)-2-fluoro-phenyl]-pentanoic acid,
5-[4-(2-cyclopentylsulfanyl-pyridin-3-yl)-2-fluoro-phenyl]-pentanoic acid,
5-[4-(2-cyclobutylsulfanyl-pyridin-3-yl)-2-fluoro-phenyl]-pentanoic acid,
5-[4-(2-cyclobutylmethoxy-pyridin-3-yl)-2,6-difluoro-phenyl]-pentanoic acid,
5-[4-(2-cyclobutoxy-pyridin-3-yl)-2,6-difluoro-phenyl]-pentanoic acid,
5-[4-(2-cyclopropylmethoxy-pyridin-3-yl)-2,6-difluoro-phenyl]-pentanoic acid,
4-[4-(5-chloro-2,2-dimethyl-2,3-dihydro-benzofuran-7-yl)-2,6-difluoro-phenoxy]-butyric acid,
4-[4-(5-chloro-2,2-dimethyl-2,3-dihydro-benzofuran-7-yl)-2,6-difluoro-phenylsulfanyl]-butyric acid,
4-{[4-(5-chloro-2,2-dimethyl-2,3-dihydro-benzofuran-7-yl)-2,6-difluoro-phenyl]-methyl-amino}-butyric acid,
5-[4-(5-chloro-2,2-dimethyl-2,3-dihydro-benzofuran-7-yl)-2,6-difluoro-phenyl]-hexanoic acid,
4-[2,6-difluoro-4-(7-methoxy-2,2-dimethyl-2,3-dihydro-benzofuran-4-yl)-phenoxy]-butyric acid,
4-[2,6-difluoro-4-(7-methoxy-2,2-dimethyl-2,3-dihydro-benzofuran-4-yl)-phenylsulfanyl]-butyric acid,
4-{[2,6-difluoro-4-(7-methoxy-2,2-dimethyl-2,3-dihydro-benzofuran-4-yl)-phenyl]-methyl-amino}-butyric acid,
5-[2,6-difluoro-4-(7-methoxy-2,2-dimethyl-2,3-dihydro-benzofuran-4-yl-phenyl]-hexanoic acid,
4-(2,6-difluoro-4-spiro[3H-benzofuran-2,1′-cyclopentan]-7-yl-phenoxy)-butyric acid,
4-(2,6-difluoro-4-spiro[3H-benzofuran-2,1′-cyclopentan]-7-yl-phenylsulfanyl)-butyric acid,
4-(2,6-difluoro-N-methyl-4-spiro[3H-benzofuran-2,1′-cyclopentan]-7-yl-anilino)-butyric acid,
5-(2,6-difluoro-4-spiro[3H-benzofuran-2,1′-cyclopentan]-7-yl-phenyl)-hexanoic acid,
7-[4-(3-carboxy-propoxy)-3,5-difluoro-phenyl]-5-fluoro-2,2-dimethyl-2,3-dihydro-indol-1-carboxylic acid methyl ester,
4-[2,6-difluoro-4-(5-fluoro-2,2-dimethyl-2,3-dihydro-1H-indol-7-yl)-phenoxy]-butyric acid,
4-[4-(3-carboxy-propoxy)-3,5-difluoro-phenyl]-5-fluoro-2,2-dimethyl-2,3-dihydro-indol-1-carboxylic acid methyl ester,
4-[2,6-difluoro-4-(5-fluoro-2,2-dimethyl-2,3-dihydro-1H-indol-4-yl)-phenoxy]-butyric acid,
4-[2,6-difluoro-4-(5-fluoro-2,2-dimethyl-2,3-dihydro-1H-indol-7-yl)-phenylsulfanyl]-butyric acid,
3-[6-(2-isopropylsulfanyl-pyridin-3-yl)-thiochroman-2-yl]-propionic acid,
3-[6-(2-cyclopentoxy-pyridin-3-yl)-thiochroman-2-yl]-propionic acid,
3-[6-(2-cyclobutylsulfanyl-pyridin-3-yl)-chroman-2-yl]-propionic acid,
3-[6-(7-methoxy-2,2-dimethyl-2,3-dihydro-benzofuran-4-yl)-chroman-2-yl]-propionic acid,
3-[6-(7-methoxy-2,2-dimethyl-2,3-dihydro-benzofuran-4-yl)-thiochroman-2-yl]-propionic acid,
3-[6-(2-cyclobutylsulfanyl-pyridin-3-yl)-thiochroman-2-yl]-propionic acid,
3-[6-(2-cyclopropylmethoxy-pyridin-3-yl)-chroman-2-yl]-propionic acid,
3-[6-(2-cyclobutoxy-pyridin-3-yl)-chroman-2-yl]-propionic acid,
3-[6-(2-cyclobutoxy-pyridin-3-yl)-thiochroman-2-yl]-propionic acid,
3-[6-(2-cyclopropylmethoxy-pyridin-3-yl)-thiochroman-2-yl]-propionic acid,
3-[6-(2-cyclopentylsulfanyl-pyridin-3-yl)-chroman-2-yl]-propionic acid,
3-[6-(2-cyclopentylsulfanyl-pyridin-3-yl)-thiochroman-2-yl]-propionic acid,
3-[6-(5-chloro-2,2-dimethyl-2,3-dihydro-benzofuran-7-yl)-thiochroman-2-yl]-propionic acid,
3-(6-spiro[3H-benzofuran-2,1′-cyclopentan]-7-yl-thiochroman-2-yl)-propionic acid,
3-{6-[2-(tetrahydro-pyran-4-yloxy)-pyridin-3-yl]-thiochroman-2-yl}-propionic acid,
{1-[2,6-difluoro-4-(7-methoxy-2,2-dimethyl-2,3-dihydro-benzofuran-4-yl)-phenyl]-azetidin-3-yl}-acetic acid,
3-[6-(6-isopropylsulfanyl-pyridin-2-yl)-thiochroman-2-yl]-propionic acid,
4-(2,6-difluoro-4-spiro[1,3-benzodioxol-2,1′-cyclopentan]-4-yl-phenoxy)butanoic acid,
4-(4-spiro[1,3-benzodioxol-2,1′-cyclopentan]-4-ylphenoxy)butanoic acid,
4-(2-fluoro-4-spiro[1,3-benzodioxol-2,1′-cyclopentan]-4-yl-phenoxy)butanoic acid,
4-[4-(2,2-difluoro-benzo[1,3]dioxol-4-yl)-2,6-difluoro-phenoxy]-butyric acid,
4-[4-(2,2-dimethyl-2,3-dihydro-benzofuran-4-yl)-2,6-difluoro-phenoxy]-butyric acid,
4-[4-(2-cyclohexylsulfanyl-pyridin-3-yl)-2,6-difluoro-phenoxy]-butyric acid,
3-[4-(2-cyclopentyloxy-pyridin-3-yl)-benzylsulfanyl]-propionic acid,
2-[1-[4-[6-(cyclobutoxy)-2-pyridyl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[2,6-difluoro-4-(6-propoxy-2-pyridyl)phenyl]-4-piperidyl]acetic acid,
2-[1-[2,6-difluoro-4-(6-isopropoxy-2-pyridyl)phenyl]-4-piperidyl]acetic acid,
2-[1-[4-(6-cyclobutylsulfanyl-2-pyridyl)-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[2,6-difluoro-4-(6-propylsulfanyl-2-pyridyl)phenyl]-4-piperidyl]acetic acid,
2-[1-[4-[6-(cyclopentoxy)-2-pyridyl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[4-[3-(cyclobutoxy)phenyl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[4-[3-(cyclopropylmethoxy)phenyl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[2,6-difluoro-4-[3-(isopropoxymethyl)phenyl]phenyl]-4-piperidyl]acetic acid,
2-[1-[4-[3-(ethoxymethyl)phenyl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[4-[3-(cyclobutoxy)-4-fluoro-phenyl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[4-[3-(cyclobutoxy)-4-methoxy-phenyl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[4-[3-(cyclobutoxy)-5-fluoro-phenyl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[2-chloro-4-[6-(cyclopropylmethoxy)-2-pyridyl]-6-fluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[4-[6-(cyclobutylmethoxy)-2-pyridyl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[4-(6-tert-butoxy-2-pyridyl)-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[4-[3-(cyclobutoxy)-2-methyl-phenyl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[4-[5-chloro-6-(cyclobutoxy)-2-pyridyl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[4-[6-(cyclopropanecarbonyl)-2-pyridyl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[4-[6-(cyclobutoxymethyl)-2-pyridyl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[4-(6-ethoxy-2-pyridyl)-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[2,6-difluoro-4-[6-(2,2,2-trifluoroethoxy)-2-pyridyl]phenyl]-4-piperidyl]acetic acid,
2-[1-[2,6-difluoro-4-[6-(2,2,2-trifluoro-1-methyl-ethoxy)-2-pyridyl]phenyl]-4-piperidyl]acetic acid,
2-[1-[4-(6-cyclopentyl-2-pyridyl)-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[4-[6-[cyclopropyl(methoxy)methyl]-2-pyridyl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[2-chloro-4-[6-(cyclobutoxy)-2-pyridyl]-6-fluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[4-[6-(cyclobutoxy)-2-pyridyl]-2-fluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[4-[6-(cyclobutoxy)-2-pyridyl]-2,6-difluoro-phenyl]azetidin-3-yl]acetic acid,
2-[1-[4-[6-(cyclopropylmethoxy)-2-pyridyl]-2,6-difluoro-phenyl]azetidin-3-yl]acetic acid,
2-[1-[4-(6-butoxy-2-pyridyl)-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[4-[2-(cyclobutoxy)thiazol-4-yl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[4-[6-(cyclobutoxy)-4-methyl-2-pyridyl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[4-[6-(cyclopentylamino)-2-pyridyl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[4-[5-(cyclobutoxy)-3-methyl-isothiazol-4-yl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
{1-[4-(4-ethoxy-thiazol-2-yl)-2,6-difluoro-phenyl]-piperidin-4-yl}acetic acid,
{1-[4-(4-ethoxy-5-methyl-thiazol-2-yl)-2,6-difluoro-phenyl]-piperidin-4-yl}acetic acid,
2-[1-[4-(6-cyclobutyl-2-pyridyl)-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[4-[6-(cyclobutylmethyl)-2-pyridyl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[4-[6-(cyclopentylmethyl)-2-pyridyl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
{1-[4-(4-cyclopropylmethoxy-thiazol-2-yl)-2,6-difluoro-phenyl]-piperidin-4-yl}acetic acid,
(1-{2,6-difluoro-4-[4-(4-fluoro-phenyl)-thiazol-2-yl]-phenyl}-piperidin-4-yl)-acetic acid,
{1-[4-(4-cyclobutoxy-thiazol-2-yl)-2,6-difluoro-phenyl]-piperidin-4-yl}acetic acid,
{1-[4-(4-butoxy-thiazol-2-yl)-2,6-difluoro-phenyl]-piperidin-4-yl}acetic acid,
2-(1-{2,6-difluoro-4-[7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]phenyl}piperidin-4-yl)acetic acid,
2-[1-[4-(6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
4-[2-chloro-4-[6-(cyclobutoxy)-2-pyridyl]-6-fluoro-phenoxy]butanoic acid,
4-[2,6-dichloro-4-[6-(cyclobutoxy)-2-pyridyl]phenoxy]butanoic acid,
4-[4-[3-(cyclopropylmethoxymethyl)-2-furyl]-2,6-difluoro-phenoxy]butanoic acid,
4-[4-[6-(cyclopropylmethoxymethyl)-2-pyridyl]-2,6-difluoro-phenoxy]butanoic acid,
4-[2-chloro-4-[3-(cyclobutoxy)-5-fluoro-phenyl]-6-fluoro-phenoxy]butanoic acid,
4-[4-[3-(cyclopropylmethoxymethyl)-5-methyl-isoxazol-4-yl]-2,6-difluoro-phenoxy]butanoic acid,
4-[4-[6-chloro-4-(cyclobutoxy)-2-pyridyl]-2,6-difluoro-phenoxy]butanoic acid,
4-[4-[2-(cyclobutoxy)thiazol-4-yl]-2,6-difluoro-phenoxy]butanoic acid,
4-[4-[6-(cyclobutoxy)-4-methyl-2-pyridyl]-2,6-difluoro-phenoxy]butanoic acid,
4-[4-[2-(cyclopropylmethoxy)thiazol-4-yl]-2,6-difluoro-phenoxy]butanoic acid,
4-[2-chloro-4-(6-cyclopentyloxy-pyridin-2-yl)-6-fluoro-phenoxy]-butyric acid,
4-[2-chloro-4-(6-cyclopropylmethoxy-pyridin-2-yl)-6-fluoro-phenoxy]-butyric acid,
4-[2-chloro-6-fluoro-4-(6-isopropoxy-pyridin-2-yl)-phenoxy]-butyric acid,
4-[2-chloro-4-(6-cyclobutylsulfanyl-pyridin-2-yl)-6-fluoro-phenoxy]-butyric acid,
4-[2-chloro-6-fluoro-4-(6-isopropylsulfanyl-pyridin-2-yl)-phenoxy]-butyric acid,
4-(5-chloro-3′-cyclobutoxy-3-fluoro-biphenyl-4-yloxy)-butyric acid,
4-(5-chloro-3′-cyclopropylmethoxy-3-fluoro-biphenyl-4-yloxy)-butyric acid,
4-(5-chloro-3′-cyclopropylmethoxy-3-fluoro-4′-methoxy-biphenyl-4-yloxy)-butyric acid,
4-(5-chloro-3′-cyclopropylmethoxy-3,4′-difluoro-biphenyl-4-yloxy)-butyric acid,
4-(3′-cyclobutylsulfanyl-3,5-difluoro-biphenyl-4-yloxy)-butyric acid,
5-(3′-cyclobutoxy-3,5-difluoro-biphenyl-4-yl)-hexanoic acid,
5-(5′-cyclobutoxy-3,5,3′-trifluoro-biphenyl-4-yl)-hexanoic acid,
5-(3′-cyclopropylmethoxy-3,5-difluoro-4′-methoxy-biphenyl-4-yl)-hexanoic acid,
5-(3′-cyclopropylmethoxy-3,5-difluoro-biphenyl-4-yl)-hexanoic acid,
5-(5′-cyclobutoxy-3′-fluoro-biphenyl-4-yl)-5,5-difluoro-pentanoic acid,
5-[4-(5-chloro-6-cyclobutoxy-pyridin-2-yl)-2,6-difluoro-phenyl]-hexanoic acid,
4-(3′-cyclobutanesulfonyl-3,5-difluoro-biphenyl-4-yloxy)-butyric acid,
5-({[4-(6-cyclobutoxy-pyridin-2-yl)-phenyl]-methyl-amino}-methyl)-isoxazol-3-ol,
4-[2-chloro-4-(6-chloro-4-cyclobutoxy-pyridin-2-yl)-6-fluoro-phenoxy]-butyric acid,
4-[2-chloro-4-(2-cyclobutoxy-thiazol-4-yl)-6-fluoro-phenoxy]-butyric acid,
4-[2-chloro-4-(2-cyclopropylmethoxy-thiazol-4-yl)-6-fluoro-phenoxy]-butyric acid,
4-[2-chloro-4-(6-cyclobutoxy-4-methyl-pyridin-2-yl)-6-fluoro-phenoxy]-butyric acid,
4-[2-chloro-4-(6-cyclopropylmethoxy-4-methyl-pyridin-2-yl)-6-fluoro-phenoxy]-butyric acid,
{(R)-1-[4-(6-cyclopropylmethoxy-pyridin-2-yl)-2,6-difluoro-phenyl]-pyrrolidin-3-yl}-acetic acid,
{1-[4-(2,2-difluoro-benzo[1,3]dioxol-4-yl)-2,6-difluoro-phenyl]-piperidin-4-yl}-acetic acid,
3-[8-fluoro-6-(2-isopropylsulfanyl-3-pyridyl)thiochroman-2-yl]propanoic acid,
3-[6-[6-(cyclobutoxy)-2-pyridyl]thiochroman-2-yl]propanoic acid,
3-[2-[2,6-difluoro-4-(7-methoxy-2,2-dimethyl-3H-benzofuran-4-yl)phenyl]cyclopropyl]propanoic acid,
3-[2-(2,6-difluoro-4-spiro[3H-benzofuran-2,1′-cyclopentan]-7-yl-phenyl)cyclopropyl]propanoic acid,
3-[6-[6-(cyclobutoxy)-2-pyridyl]chroman-2-yl]propanoic acid,
3-[6-[6-(cyclopropylmethoxy)-2-pyridyl]chroman-2-yl]propanoic acid,
4-[4-(2,3-dimethoxyphenyl)-2,6-difluoro-phenoxy]butanoic acid,
3-[6-[3-(cyclopropylmethoxy)phenyl]chroman-2-yl]propanoic acid,
3-[6-[3-(cyclopentoxy)phenyl]chroman-2-yl]propanoic acid,
4-(2,6-difluoro-N-methyl-4-spiro[1,3-benzodioxol-2,1′-cyclopentan]-4-yl-anilino)butanoic acid,
5-(2,6-difluoro-4-spiro[1,3-benzodioxol-2,1′-cyclopentan]-4-yl-phenyl)hexanoic acid,
3-[6-(6-tert-butylsulfanyl-2-pyridyl)chroman-2-yl]propanoic acid,
3-[6-(6-isopropoxy-2-pyridyl)chroman-2-yl]propanoic acid,
2-[1-(2,6-difluoro-4-spiro[1,3-benzodioxol-2,1′-cyclopentan]-4-yl-phenyl)-4-piperidyl]acetic acid,
4-[4-(2,3-dipropoxyphenyl)-2,6-difluoro-phenoxy]butanoic acid,
4-[4-[6-(cyclobutoxy)-5-methoxy-2-pyridyl]-2,6-difluoro-phenoxy]butanoic acid,
4-[4-[6-(cyclobutoxy)-5-methoxy-2-pyridyl]-2,6-difluoro-N-methyl-anilino]butanoic acid,
2-[1-[4-[6-(cyclobutoxy)-5-methoxy-2-pyridyl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
2-[1-[4-(2,3-dipropoxyphenyl)-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
4-[4-[6-(cyclopropylmethoxy)-5-methoxy-2-pyridyl]-2,6-difluoro-phenoxy]butanoic acid,
4-[4-(2,3-dipropoxyphenyl)-2,6-difluoro-N-methyl-anilino]butanoic acid,
4-[4-[6-(cyclopropylmethoxy)-5-methoxy-2-pyridyl]-2,6-difluoro-N-methyl-anilino]butanoic acid,
2-[1-[4-[6-(cyclopropylmethoxy)-5-methoxy-2-pyridyl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
4-[4-(6-chloroindol-1-yl)-2,6-difluoro-phenoxy]butanoic acid,
5-[4-[6-(cyclobutoxy)-5-methoxy-2-pyridyl]phenyl]-5,5-difluoro-pentanoic acid,
4-[2,6-difluoro-4-(5-fluoroindol-1-yl)phenoxy]butanoic acid,
4-[4-[3-(cyclopropylmethylamino)phenyl]-2,6-difluoro-N-methyl-anilino]butanoic acid,
4-[2,6-difluoro-N-methyl-4-(6-pyrrolidin-1-yl-2-pyridyl)anilino]butanoic acid,
4-[2,6-difluoro-4-(5-methoxyindol-1-yl)phenoxy]butanoic acid,
4-[4-(5-cyanoindol-1-yl)-2,6-difluoro-phenoxy]butanoic acid,
4-[4-[3-(cyclopropylmethoxymethyl)-2-furyl]-2,6-difluoro-N-methyl-anilino]butanoic acid,
4-[2,6-difluoro-4-(4-fluoroindol-1-yl)phenoxy]butanoic acid,
4-[4-(7-chloroindol-1-yl)-2,6-difluoro-phenoxy]butanoic acid,
4-[4-[5-(cyclopropylmethoxymethyl)-2-furyl]-2,6-difluoro-N-methyl-anilino]butanoic acid,
4-[4-[6-(cyclopropylmethoxy)indol-1-yl]-2,6-difluoro-phenoxy]butanoic acid,
4-[4-(7-chloroindol-1-yl)-2,6-difluoro-N-methyl-anilino]butanoic acid,
4-[4-[6-(cyclobutoxy)indol-1-yl]-2,6-difluoro-phenoxy]butanoic acid,
4-[4-[5-(cyclobutoxy)indol-1-yl]-2,6-difluoro-phenoxy]butanoic acid,
4-[2,6-difluoro-4-(4-methoxyindol-1-yl)phenoxy]butanoic acid,
4-[2,6-difluoro-4-(7-methoxyindol-1-yl)phenoxy]butanoic acid,
4-[2,6-difluoro-4-[5-(methoxymethyl)indazol-1-yl]phenoxy]butanoic acid,
2-[1-[4-(7-chloroindol-1-yl)-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
4-[4-[6-(cyclobutoxy)indazol-1-yl]-2,6-difluoro-phenoxy]butanoic acid,
4-[2-chloro-4-[6-(cyclobutoxy)indazol-1-yl]-6-fluoro-phenoxy]butanoic acid,
4-[4-[2-(cyclobutoxy)thiazol-4-yl]-2,6-difluoro-N-methyl-anilino]butanoic acid,
2-[1-[4-[6-(cyclobutoxy)indazol-1-yl]-2,6-difluoro-phenyl]-4-piperidyl]acetic acid,
4-[4-[6-(cyclobutoxy)indazol-1-yl]-2,6-difluoro-N-methyl-anilino]butanoic acid,
4-[4-[6-(cyclopropylmethoxy)-2-pyridyl]-2,6-difluoro-N-methyl-anilino]butanoic acid,
2-[1-[4-[6-(cyclobutoxy)indazol-1-yl]-2,6-difluoro-phenyl]pyrrolidin-3-yl]acetic acid,
4-[4-(5-chloro-2-methyl-benzofuran-7-yl)-2,6-difluoro-phenoxy]-butyric acid,
5-[4-(5-chloro-2-methyl-benzofuran-7-yl)-2,6-difluoro-phenyl]-hexanoic acid,
4-[(3′-cyclobutylmethoxy-3,5-difluoro-biphenyl-4-yl)-methyl-amino]-butyric acid,
4-(3′-cyclobutylmethoxy-3,5-difluoro-biphenyl-4-yloxy)-butyric acid,
4-{[4-(6-cyclobutylmethoxy-pyridin-2-yl)-2,6-difluoro-phenyl]-methyl-amino}-butyric acid,
4-[4-(6-cyclobutylmethoxy-pyridin-2-yl)-2,6-difluoro-phenoxy]-butyric acid,
4-[(3′-cyclopropylmethoxy-3,5-difluoro-biphenyl-4-yl)-methyl-amino]-butyric acid,
4-[(3′-cyclopentyloxy-3,5-difluoro-biphenyl-4-yl)-methyl-amino]-butyric acid,
4-(3′-cyclopropylmethoxy-3,5-difluoro-4′-methoxy-biphenyl-4-yloxy)-butyric acid,
4-(3′-cyclopropylmethoxy-3,5,4′-trifluoro-biphenyl-4-yloxy)-butyric acid,
4-(5′-cyclobutoxy-3,5,3′-trifluoro-biphenyl-4-yloxy)-butyric acid,
4-[(5′-cyclobutylmethoxy-3,5-difluoro-2′-methyl-biphenyl-4-yl)-methyl-amino]-butyric acid,
4-(5′-cyclobutylmethoxy-3,5-difluoro-2′-methyl-biphenyl-4-yloxy)-butyric acid,
4-{[4-(5-chloro-6-cyclobutoxy-pyridin-2-yl)-2,6-difluoro-phenyl]-methyl-amino}-butyric acid,
4-(3′-cyclopropylmethoxy-3,5-difluoro-4′-methyl-biphenyl-4-yloxy)-butyric acid,
4-[4-(5-chloro-6-cyclobutoxy-pyridin-2-yl)-2,6-difluoro-phenoxy]-butyric acid,
4-(4′-chloro-3′-cyclopropylmethoxy-3,5-difluoro-biphenyl-4-yloxy)-butyric acid,
5-(5′-cyclobutoxy-3,3′-difluoro-biphenyl-4-yl)-pentanoic acid,
4-(5′-cyclobutoxy-3,3′-difluoro-biphenyl-4-yloxy)-butyric acid,
5-[4-(6-cyclobutoxy-pyridin-2-yl)-2-fluoro-phenyl]-pentanoic acid,
4-[4-(6-cyclobutoxy-pyridin-2-yl)-2-fluoro-phenoxy]-butyric acid,
4-[4-(6-cyclobutylmethoxy-pyridin-2-yl)-2-fluoro-phenoxy]-butyric acid,
4-[4-(6-cyclobutylsulfanyl-pyridin-2-yl)-2-fluoro-phenoxy]-butyric acid,
2-(3′-cyclobutoxy-3,5,5′-trifluoro-biphenyl-4-yloxymethyl)-cyclopropane carboxylic acid,
2-[4-(6-cyclobutoxy-pyridin-2-yl)-2,6-difluoro-phenoxymethyl]-cyclopropane carboxylic acid,
2-[4-(6-cyclobutoxy-4-methyl-pyridin-2-yl)-2,6-difluoro-phenoxymethyl]-cyclopropane carboxylic acid,
2-[4-(6-cyclopropylmethoxy-pyridin-2-yl)-2,6-difluoro-phenoxymethyl]-cyclopropane carboxylic acid,
2-[4-(2-cyclobutoxy-thiazol-4-yl)-2,6-difluoro-phenoxymethyl]-cyclopropane carboxylic acid,
2-[2-chloro-4-(6-cyclopropylmethoxy-pyridin-2-yl)-6-fluoro-phenoxymethyl]-cyclopropane carboxylic acid,
2-[2-chloro-4-(6-cyclobutoxy-pyridin-2-yl)-6-fluoro-phenoxymethyl]-cyclopropane carboxylic acid,
3-[6-(3-cyclobutoxy-phenyl)-chroman-2-yl]-propionic acid,
3-[6-(6-propoxy-pyridin-2-yl)-chroman-2-yl]-propionic acid,
4-[2,6-difluoro-4-(1H-indol-6-yl)-phenoxy]-butanoic acid,
4-[2,6-difluoro-4-(1-isopropyl-1H-indol-6-yl)-phenoxy]-butanoic acid,
4-[4-(1-cyclopropylmethyl-1H-indol-6-yl)-2,6-difluoro-phenoxy]-butanoic acid
{1-[4-(6-cyclopropylmethoxy-pyridin-2-yl)-2,6-difluoro-phenyl]-pyrrolidin-3-yl}-acetic acid,
{1-[4-(6-cyclobutoxy-pyridin-2-yl)-2,6-difluoro-phenyl]-pyrrolidin-3-yl}-acetic acid,
4-[4-(3-chloro-1-isopropyl-1H-indol-6-yl)-2,6-difluoro-phenoxy]-butanoic acid,
{1-[2,6-difluoro-4-(6-isopropoxy-pyridin-2-yl)-phenyl]-pyrrolidin-3-yl}-acetic acid,
{1-[4-(6-cyclobutylmethoxy-pyridin-2-yl)-2,6-difluoro-phenyl]-pyrrolidin-3-yl}-acetic acid,
4-[4-(5-cyclopropylmethoxymethyl-thiophen-2-yl)-2,6-difluoro-phenoxy]-butanoic acid,
4-[4-(5-cyclopropylmethoxymethyl-thiophen-3-yl)-2,6-difluoro-phenoxy]-butanoic acid,
{1-[4-(5-cyclopropylmethoxymethyl-thiophen-3-yl)-2,6-difluoro-phenyl]-piperidin-4-yl}-acetic acid,
4-[4-(4-cyclopropylmethoxymethyl-2-methyl-thiazol-5-yl)-2,6-difluoro-phenoxy]-butanoic acid,
{1-[4-(5-cyclomethoxymethyl-thiophen-2-yl)-2,6-difluoro-phenyl]-piperidin-4-yl}-acetic acid,
{1-[4-(4-cyclopropylmethoxymethyl-2-methyl-thiazol-5-yl)-2,6-difluoro-phenyl]-piperidin-4-yl}-acetic acid,
4-[4-(5-cyclobutylmethoxymethyl-thiophen-3-yl)-2,6-difluoro-phenoxy]-butanoic acid,
4-[2,6-difluoro-4-(5-isobutoxymethyl-thiophen-3-yl)-phenoxy]-butanoic acid,
4-[4-(5-cyclobutoxymethyl-thiophen-3-yl)-2,6-difluoro-phenoxy]-butanoic acid,
4-[4-(3-cyclopropylmethoxymethyl-thiophen-2-yl)-2,6-difluoro-phenoxy]-butanoic acid,
{1-[4-(6-cyclobutoxy-4-methyl-pyridin-2-yl)-2,6-difluoro-phenyl]-pyrrolidin-3-yl}-acetic acid,
{1-[4-(2-cyclobutoxy-thiazol-4-yl)-2,6-difluoro-phenyl]-pyrrolidin-3-yl}-acetic acid,
{1-[4-(2-cyclopropylmethoxy-thiazol-4-yl)-2,6-difluoro-phenyl]-pyrrolidin-3-yl}-acetic acid,
{1-[4-(5-cyclobutoxy-3-methyl-isothiazol-4-yl)-2,6-difluoro-phenyl]-pyrrolidin-3-yl}-acetic acid,
{1-[2,6-difluoro-4-(5-fluoro-4-isobutoxy-pyrimidin-2-yl)-phenyl]-pyrrolidin-3-yl}-acetic acid,
(1-{2,6-difluoro-4-[6-(3-methoxy-propoxy)-pyridin-2-yl]-phenyl}-pyrrolidin-3-yl)-acetic acid,
(1-{2,6-difluoro-4-[6-(tetrahydro-thiopyran-4-yloxy-pyridin-2-yl]-phenyl}-pyrrolidin-3-yl)-acetic acid,
(1-{2,6-difluoro-4-[6-(3-methoxy-propoxy)-pyridin-2-yl]-phenyl}-piperidin-4-yl)-acetic acid,
{(S)-1-[4-(6-cyclopropylmethoxy-pyridin-2-yl)-2,6-difluoro-phenyl]-pyrrolidin-3-yl}-acetic acid,
{1-[4-(6-cyclobutoxy-4-trifluoromethyl-pyridin-2-yl)-2,6-difluoro-phenyl]-piperidin-4-yl}-acetic acid,
(1-{2,6-difluoro-4-[2-(4-fluoro-phenyl)-benzo[b]thiophen-4-yl]-phenyl}-piperidin-4-yl)-acetic acid,
{1-[2,6-difluoro-4-(2-m-tolyl-benzo[b]thiophen-4-yl)-phenyl]-piperidin-4-yl}-acetic acid,
3-{1-[2,6-difluoro-4-(6-propoxy-pyridin-2-yl)-phenyl]-piperidin-4-yl}-propionic acid,
3-{1-[4-(6-cyclobutyl-pyridin-2-yl)-2,6-difluoro-phenyl]-piperidin-4-yl}-propionic acid, and
3-{1-[4-(6-ethoxy-pyridin-2-yl)-2,6-difluoro-phenyl]-piperidin-4-yl}-propionic acid,
or a pharmaceutically acceptable salt or stereoisomer thereof.

485 more elements

Biaryl derivative as gpr120 agonist

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Biaryl derivative as gpr120 agonist

Life of this patent

Abstract

Claims5