Multivalent Live-attenuated Influenza Vaccine for Prevention and Control of Equine Influenza Virus (EIV) in Horses
AssigneesUniversity of Rochester, University of Kentucky Research Foundation, Zoetis Services LLC
InventorsLuis Martinez-Sobrido, Thomas Chambers, Kendall Wayne King
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Abstract
The present invention provides compositions and methods related to equine live-attenuated influenza vaccines. In one aspect, the invention relates to a composition comprising a multivalent equine live-attenuated influenza vaccine comprising a first live-attenuated influenza virus expressing one or more antigens of a clade 1 H3N8 equine influenza virus; and a second live-attenuated influenza virus expressing one or more antigens of a clade 2 H3N8 equine influenza virus, wherein the second live-attenuated influenza virus expresses HA, NA, or a combination thereof of A/equine/Lancashire/1/2016 H3N8.
Claims21
A multivalent immunological composition comprising two or more equine live-attenuated influenza viruses (LAIV), comprising:
- a first LAIV expressing one or more antigens of a clade 1 H3N8 equine influenza virus;
- and
- a second LAIV expressing one or more antigens of a clade 2 H3N8 equine influenza virus, wherein the second LAIV expresses HA, NA, or a combination thereof of A/equine/Lancashire/1/2016 H3N8
- wherein each LAIV comprises one or more mutations in one or more of:
- segment 1 and segment 2 of the viral genome.
Dependencies are inferred from the claim text.