Reagent kit for lc-ms analysis of aromatic compounds

A reagent kit for LC-MS analysis of aromatic compounds, comprising a diazonium reagent, wherein the diazonium reagent is contacted with the aromatic compounds in a sample to form a first analyte, then by measuring an amount or ratio of the first analyte to the sample that has been formed by liquid chromatography-mass spectrometry analyzing, presence or quantity of the aromatic compounds in the sample is extrapolated;

• wherein the diazonium reagent contains one or more functional groups that can be negatively or positively charged during liquid chromatography-mass spectrometry analyzing;
• the functional groups can be negatively charged in the diazonium reagent comprise one or more of sulfonate group (—SO3−), carboxylate group (—COO−), sulfonic acid group (—SO3H) and carboxylic acid group (—COOH), and the functional groups that can be positively charged in the diazonium reagent include one or more of quaternary ammonium group, amino group and thiol group;
• wherein the diazonium reagent is p-sulfanilic acid diazonium salt solution, Fast Red RC Diazonium Salt or Fast Red TR Diazonium Salt;
• wherein when the diazonium reagent is p-sulfanilic acid diazonium salt solution, the aromatic compounds in the sample is Estriol or Estradiol;
• and
• wherein when the diazonium reagent is Fast Red RC Diazonium Salt or Fast Red TR Diazonium Salt, the aromatic compounds in the sample is cannabidiol compounds, Estriol or Estradiol.