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US 2022/0127206 A1Published application
Method for introducing deuterated lower alkyl into amine moiety of compound containing secondary amine
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorsMasahiro MIYAKE, Masashi HAYASHI, Yuya NAKAI
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Abstract
The present invention relates to a method of mono-deuterated-lower-alkylating the amine part in a compound having an amine protected with an aralkyl, which comprises introducing mono-deuterated lower-alkyl into the amine with a deuterated-lower-alkylating agent under neutral or basic condition, and then deprotecting the aralkyl group.
Claims10
A method of introducing a mono-deuterated lower-alkyl into a secondary amine in a compound having the secondary amine, comprising
- replacing the hydrogen atom in the secondary amine by an aralkyl,
- lower-alkylating the obtained tertiary amine with a deuterated-lower-alkylating agent under neutral or basic condition, and then
- eliminating the aralkyl group.
Dependencies are inferred from the claim text.