US 2022/0126260 A1 · PEPTIDE SYNTHESIS INSTRUMENTATION

Abstract

A peptide synthesis instrument can be used for small scale peptide synthesis. The instrument can include several unique features, including a compression style reaction vessel permitting quick setup of the reaction vessel, a double reaction vessel system permitting efficient mixing without loss of solvent or solvent-to-resin contact, gravity-fed heated reservoirs establishing a fixed volume for delivery to the reaction vessel, fume-free solvent addition permitting solvent addition to fixed bottles, and an improved amino acid manifold assembly which reduces the number of components and increases the ease of use of the instrument. Each of these features improve upon the current state of the art in solid phase automated peptide synthesizers.

Claims20

Dependent claims

A solvent delivery system for a chemical synthesis device, comprising:

a solvent bottle;
a solvent reservoir operable to receive solvent from the solvent bottle via a fluid connection;
a first valve at an inlet to the solvent reservoir, the first valve configured to, in a first position, provide solvent from the solvent bottle into the solvent reservoir and, in a second position, provide a pressurized gas flow into the solvent reservoir;
and
a second valve at an outlet of the solvent reservoir, the second valve configured to, in a second valve first position, provide flow out of the solvent reservoir and back to the solvent bottle and, in a second valve second position, provide flow from the solvent reservoir to the chemical synthesis device.

2 more elements

Dependencies are inferred from the claim text.

Peptide synthesis instrumentation

Life of this patent

Peptide synthesis instrumentation

Life of this patent

Abstract

Claims20