Chemiluminescence photodynamic virus inactivation of red blood cells
AssigneeTrevor P. Castor
InventorsTrevor Percival Castor, Vasudevacharya Jayarama
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Abstract
The present invention is directed to methods, kits and compositions for inactivating viral agents in or on articles including blood-based products and feature a light sensitive compound selected from the group consisting of hypericin, pseudohypericin and hypocrellin, a group of light producing compounds comprising luciferase, luciferin, ATP and CDP Star, and emission enhancers or quenchers selected from the group consisting of as Sapphire, Emerald, Ruby, Sapphire-II and Emerald-II.
Claims17
A method for inactivating a viral agent comprising the steps of placing an article potentially having a viral agent in the presence of an admixture consisting of a light sensitive compound, a group of light producing compounds, and emission enhancers wherein said light sensitive compound is selected from the group consisting of hypericin, pseudohypericin and hypocrellin, said group of light producing compound is selected from the group consisting of luciferase, luciferin, ATP and CDP Star, and said emission enhancers or quenchers selected from the group consisting of as Sapphire, Emerald, Ruby, Sapphire-II and Emerald-II at concentrations for a period of time sufficient for light producing reactions to produce light sufficient to react with said light sensitive compound and said viral agent to inactivate said viral agent.
A kit for inactivating a viral agent comprising:
- means for forming an admixture in an article or on an article which potentially has viral agent/s and instructions, said means for forming an admixture consisting of a light sensitive compound, a group of light producing compounds and emission enhancers, wherein said light sensitive compound is selected from the group consisting of hypericin, pseudohypericin and hypocrellin, said group of light producing compound is selected from the group consisting of luciferase, luciferin, ATP and CDP Star, and said emission enhancers or quenchers selected from the group consisting of as Sapphire, Emerald, Ruby, Sapphire-II and Emerald-II wherein said instructions for making said admixture and designating the period of time sufficient for light producing reactions to produce light sufficient to react with light sensitive compound and said viral agent to inactivate said viral agent.
A composition for inactivating a viral agent comprising a means for forming an admixture in an article or on an article which potentially has a viral agent, said means for forming an admixture consisting of a light sensitive compound and a group of light producing compounds, wherein said light sensitive compound is selected from the group consisting of hypericin, pseudohypericin and hypocrellin, said group of light producing compound is selected from the group consisting of luciferase, luciferin, ATP and CDP Star, and said emission enhancers or quenchers selected from the group consisting of as Sapphire, Emerald, Ruby, Sapphire-II and Emerald-II wherein said means for forming an admixture is a powder for reconstitution.
Dependencies are inferred from the claim text.