Protein inhibitors with reduced immunogenicity and resistance to degradation, and methods for their preparation and use
AssigneeAmide Technologies
InventorsKyle TOTARO, Travis Ness, Brady Summers, Bradley Pentelute
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Abstract
Methods are provided to identify therapeutically useful peptides and polypeptides that bind to HR1 and may be used to treat coronavirus infections. Polypeptides and pharmaceutical compositions useful for such purposes are described.
Claims33
A mirror-image polypeptide comprising a sequence having at least 80% sequence identity to the polypeptide of SEQ ID NO:
- 1
- (ATVKFTYQGEEKQVDISKIKXVXRXGQXIXFXYDEGGGAXGXGXVSEKDAPKELL QMLEKQ);
- wherein the mirror-image polypeptide is comprised of D-amino acids and wherein X is any amino acid residue.
-7. (canceled)
A polypeptide comprising a sequence having at least 80% sequence identity to the polypeptide of SEQ ID NO:
- 9
- (ATVKFTYQGEEKQVDISKIKWVLRSGQRIWFSYDEGGGAWGYGWVSEKDAPKELL QMLEKQ) wherein the polypeptide is comprised of L-amino acids.
-13. (canceled)
-102. (canceled)
-106. (canceled)
-110. (canceled)
-143. (canceled)
(canceled)
-150. (canceled)
-154. (canceled)
-158. (canceled)
Dependencies are inferred from the claim text.