Exercise-induced circulatory factors for amelioration of cognitive, neurological, and regenerative dysfunction during aging
AssigneeThe Regents of the University of California
InventorsSaul A. Villeda, Alana Horowitz, Xuelai Fan
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Abstract
Provided herein are glycosylphosphatidylinositol-specific phospholipase D1 (Gpld1) polypeptide compositions and methods for improving cognitive function and/or motor impairment in an individual comprising treatment with a Gpld1 polypeptide.
Claims22
A method of treating or preventing age-related cognitive dysfunction in an individual in need thereof, the method comprising
- administering to the individual an effective amount of a phosphatidylinositol-glycan-specific phospholipase D1 (Gpld1) polypeptide that comprises the catalytic domain, wherein the Gpld1 polypeptide has catalytic activity and is administered systemically or locally to the brain,
- thereby treating or preventing age-related cognitive dysfunction.
A method of treating or preventing age-related cognitive dysfunction in an individual in need thereof, the method comprising introducing a nucleic acid construct encoding a Gpld1 polypeptide into the individual, optionally wherein the nucleic acid is introduced into the liver.
(canceled)
A method of treating or preventing age-related cognitive dysfunction in an individual in need thereof, the method comprising genetically modifying cells of an individual to enhance expression of a Gpld1 polypeptide into the individual, wherein, optionally:
- the cells are hepatocytes;
- and/or
- the cells are modified ex vivo and administered to the individual;
- and/or
- the individual has mild cognitive impairment, dementia, or Alzheimer's disease.
-26. (canceled)
Dependencies are inferred from the claim text.